OSMR β Antibody (C-12): sc-376511
- OSMR β Antibody (C-12) is a mouse monoclonal IgG2a κ OSMR β antibody, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 782-971 mapping at the C-terminus of OSMR β of mouse origin
- OSMR beta Antibody (C-12) is recommended for detection of OSMR β of mouse origin by WB, IP, IF, IHC(P) and ELISA
- Anti-OSMR beta Antibody (C-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for OSMR β Antibody (C-12). This work is in progress.
QUICK LINKS
OSMR β Antibody (C-12) is a mouse monoclonal IgG2a kappa light chain antibody that detects OSMR beta protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-OSMR beta antibody (C-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. OSMR beta protein plays a crucial role in mediating the effects of Oncostatin M (OSM), a glycoprotein that inhibits the growth of various human tumor cell lines while sparing normal human fibroblasts. This selective inhibition is vital for potential therapeutic applications in cancer treatment, as OSM can target malignant cells without adversely affecting normal tissue. OSMR beta is predominantly expressed in activated monocytic and lymphocytic cell lines, as well as in normal adherent macrophages, highlighting its importance in immune responses and inflammation. Additionally, OSMR beta′s amino acid sequence shows homology with other key cytokines such as leukemia inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6, all involved in the growth and differentiation of various cell types, particularly those of hematopoietic origin. This functional interplay underscores OSMR beta′s relevance in both normal physiology and pathological conditions, making OSMR beta (C-12) antibody an essential tool for researchers studying these processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
OSMR β Antibody (C-12) References:
- Temporal expression of mRNAs for neuropoietic cytokines, interleukin-11 (IL-11), oncostatin M (OSM), cardiotrophin-1 (CT-1) and their receptors (IL-11Ralpha and OSMRbeta) in peripheral nerve injury. | Ito, Y., et al. 2000. Neurochem Res. 25: 1113-8. PMID: 11055749
- Oncostatin M regulates the synthesis and turnover of gp130, leukemia inhibitory factor receptor alpha, and oncostatin M receptor beta by distinct mechanisms. | Blanchard, F., et al. 2001. J Biol Chem. 276: 47038-45. PMID: 11602599
- Developmental expression pattern of oncostatin M receptor beta in mice. | Tamura, S., et al. 2002. Mech Dev. 115: 127-31. PMID: 12049776
- Complete overlap of interleukin-31 receptor A and oncostatin M receptor beta in the adult dorsal root ganglia with distinct developmental expression patterns. | Bando, T., et al. 2006. Neuroscience. 142: 1263-71. PMID: 16926070
- Oncostatin M receptor-beta signaling limits monocytic cell recruitment in acute inflammation. | Hams, E., et al. 2008. J Immunol. 181: 2174-80. PMID: 18641356
- Deficiency of oncostatin M receptor β (OSMRβ) exacerbates high-fat diet-induced obesity and related metabolic disorders in mice. | Komori, T., et al. 2014. J Biol Chem. 289: 13821-37. PMID: 24695736
- Hepatic Oncostatin M Receptor β Regulates Obesity-Induced Steatosis and Insulin Resistance. | Luo, P., et al. 2016. Am J Pathol. 186: 1278-92. PMID: 26976243
- Oncostatin M receptor β deficiency attenuates atherogenesis by inhibiting JAK2/STAT3 signaling in macrophages. | Zhang, X., et al. 2017. J Lipid Res. 58: 895-906. PMID: 28258089
- OSMRβ mutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients. | Liu, J., et al. 2021. Protein Cell. 12: 653-661. PMID: 33502684
- Suppression of renal crystal formation, inflammation, and fibrosis by blocking oncostatin M receptor β signaling. | Deguchi, R., et al. 2024. Sci Rep. 14: 28913. PMID: 39572752
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OSMR β Antibody (C-12) | sc-376511 | 200 µg/ml | $322.00 | |||
OSMR β Antibody (C-12) AC | sc-376511 AC | 500 µg/ml, 25% agarose | $424.00 | |||
OSMR β Antibody (C-12) HRP | sc-376511 HRP | 200 µg/ml | $322.00 | |||
OSMR β Antibody (C-12) FITC | sc-376511 FITC | 200 µg/ml | $336.00 | |||
OSMR β Antibody (C-12) PE | sc-376511 PE | 200 µg/ml | $349.00 | |||
OSMR β Antibody (C-12) Alexa Fluor® 488 | sc-376511 AF488 | 200 µg/ml | $364.00 | |||
OSMR β Antibody (C-12) Alexa Fluor® 546 | sc-376511 AF546 | 200 µg/ml | $364.00 | |||
OSMR β Antibody (C-12) Alexa Fluor® 594 | sc-376511 AF594 | 200 µg/ml | $364.00 | |||
OSMR β Antibody (C-12) Alexa Fluor® 647 | sc-376511 AF647 | 200 µg/ml | $364.00 | |||
OSMR β Antibody (C-12) Alexa Fluor® 680 | sc-376511 AF680 | 200 µg/ml | $364.00 | |||
OSMR β Antibody (C-12) Alexa Fluor® 790 | sc-376511 AF790 | 200 µg/ml | $364.00 |