OSM Antibody (A-9): sc-374039
- OSM Antibody (A-9) is a mouse monoclonal IgG1 κ OSM antibody, cited in 7 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 65-96 near the N-terminus of OSM of mouse origin
- OSM Antibody (A-9) is recommended for detection of precursor and mature OSM of mouse and rat origin by WB, IP, IF and ELISA
- Anti-OSM Antibody (A-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for OSM Antibody (A-9) for WB applications. These reagents are now offered in bundles with OSM Antibody (A-9) (see ordering information below).
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OSM Antibody (A-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects OSM protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-OSM antibody (A-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Oncostatin M (OSM) is a glycoprotein that plays a crucial role in regulating cell growth and differentiation, particularly in inflammation and cancer. OSM was initially isolated from the conditioned medium of U937 human histiocytic leukemia cells that had been induced to differentiate into macrophage-like cells. OSM inhibits the growth of a wide range of human tumor cell lines while sparing normal human fibroblasts, highlighting OSM′s potential as a therapeutic target in oncology. OSM interacts with high-affinity binding sites on both normal and tumor cells, and OSM expression is significantly elevated in activated monocytic and lymphocytic cell lines, as well as in normal adherent macrophages. Notably, OSM shares structural homology with other important cytokines such as leukemia inhibitory factor (LIF), granulocyte colony-stimulating factor (G-CSF), and interleukin 6 (IL-6), all of which are pivotal in modulating the growth and differentiation of various cell types, particularly those of hematopoietic origin. OSM′s ability to influence these processes underscores OSM′s importance in both normal physiology and disease states, making OSM monoclonal antibody (A-9) a valuable tool for researchers studying OSM′s diverse roles in cellular signaling and immune responses.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
OSM Antibody (A-9) References:
- Oncostatin M as a potent mitogen for AIDS-Kaposi's sarcoma-derived cells. | Miles, SA., et al. 1992. Science. 255: 1432-4. PMID: 1542793
- The IL-6 signal transducer, gp130: an oncostatin M receptor and affinity converter for the LIF receptor. | Gearing, DP., et al. 1992. Science. 255: 1434-7. PMID: 1542794
- Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. | Rose, TM. and Bruce, AG. 1991. Proc Natl Acad Sci U S A. 88: 8641-5. PMID: 1717982
- Regulation of cell growth by recombinant oncostatin M. | Horn, D., et al. 1990. Growth Factors. 2: 157-65. PMID: 2160258
- Identification and characterization of cellular receptors for the growth regulator, oncostatin M. | Linsley, PS., et al. 1989. J Biol Chem. 264: 4282-9. PMID: 2538434
- Molecular cloning, sequence analysis, and functional expression of a novel growth regulator, oncostatin M. | Malik, N., et al. 1989. Mol Cell Biol. 9: 2847-53. PMID: 2779549
- Purification and characterization of cytostatic lymphokines produced by activated human T lymphocytes. Synergistic antiproliferative activity of transforming growth factor beta 1, interferon-gamma, and oncostatin M for human melanoma cells. | Brown, TJ., et al. 1987. J Immunol. 139: 2977-83. PMID: 3117884
- Oncostatin M: a growth regulator produced by differentiated histiocytic lymphoma cells. | Zarling, JM., et al. 1986. Proc Natl Acad Sci U S A. 83: 9739-43. PMID: 3540948
- Oncostatin M is a proinflammatory mediator. In vivo effects correlate with endothelial cell expression of inflammatory cytokines and adhesion molecules. | Modur, V., et al. 1997. J Clin Invest. 100: 158-68. PMID: 9202068
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OSM Antibody (A-9) | sc-374039 | 200 µg/ml | $322.00 | |||
OSM Antibody (A-9): m-IgG Fc BP-HRP Bundle | sc-527430 | 200 µg Ab; 10 µg BP | $361.00 | |||
OSM Antibody (A-9): m-IgG1 BP-HRP Bundle | sc-532803 | 200 µg Ab; 20 µg BP | $361.00 | |||
OSM Antibody (A-9) AC | sc-374039 AC | 500 µg/ml, 25% agarose | $424.00 | |||
OSM Antibody (A-9) HRP | sc-374039 HRP | 200 µg/ml | $322.00 | |||
OSM Antibody (A-9) FITC | sc-374039 FITC | 200 µg/ml | $336.00 | |||
OSM Antibody (A-9) PE | sc-374039 PE | 200 µg/ml | $349.00 | |||
OSM Antibody (A-9) Alexa Fluor® 488 | sc-374039 AF488 | 200 µg/ml | $364.00 | |||
OSM Antibody (A-9) Alexa Fluor® 546 | sc-374039 AF546 | 200 µg/ml | $364.00 | |||
OSM Antibody (A-9) Alexa Fluor® 594 | sc-374039 AF594 | 200 µg/ml | $364.00 | |||
OSM Antibody (A-9) Alexa Fluor® 647 | sc-374039 AF647 | 200 µg/ml | $364.00 | |||
OSM Antibody (A-9) Alexa Fluor® 680 | sc-374039 AF680 | 200 µg/ml | $364.00 | |||
OSM Antibody (A-9) Alexa Fluor® 790 | sc-374039 AF790 | 200 µg/ml | $364.00 | |||
OSM (A-9) Neutralizing Peptide | sc-374039 P | 100 µg/0.5 ml | $69.00 |