OPN1LW/MW Antibody (7G8): sc-517301

OPN1LW/MW Antibody (7G8) is a mouse monoclonal IgG1 antibody that detects OPN1LW/MW in human samples through western blotting (WB). OPN1LW/MW is a crucial component of the opsin subfamily of G protein-coupled receptors, which play a vital role in the visual system by mediating the phototransduction pathway. This pathway is essential for converting light into electrical signals in the retina, allowing for the perception of color and light. OPN1LW/MW (7G8) antibody specifically detects OPN1LW protein, which is responsible for the red-sensitive phototransduction, with an absorption maximum at 560 nm, while OPN1MW is associated with green sensitivity, peaking at 530 nm. The proper functioning of these opsins is critical for normal color vision; deficiencies in these proteins can lead to color blindness conditions such as protanopia and deuteranopia. Anti-OPN1LW/MW antibody (7G8) enables researchers to effectively study the expression and function of these opsins, contributing to a deeper understanding of visual processing and potential therapeutic targets for vision-related disorders.

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OPN1LW/MW Antibody (7G8) References:

1. A novel missense mutation in both OPN1LW and OPN1MW cone opsin genes causes X-linked cone dystrophy (XLCOD5).  |  Gardner, JC., et al. 2012. Adv Exp Med Biol. 723: 595-601. PMID: 22183383
2. A 73,128 bp de novo deletion encompassing the OPN1LW/OPN1MW gene cluster in sporadic Blue Cone Monochromacy: a case report.  |  Buena-Atienza, E., et al. 2018. BMC Med Genet. 19: 107. PMID: 29940872
3. Rescue of M-cone Function in Aged Opn1mw-/- Mice, a Model for Late-Stage Blue Cone Monochromacy.  |  Deng, WT., et al. 2019. Invest Ophthalmol Vis Sci. 60: 3644-3651. PMID: 31469404
4. Intermixing the OPN1LW and OPN1MW Genes Disrupts the Exonic Splicing Code Causing an Array of Vision Disorders.  |  Neitz, M. and Neitz, J. 2021. Genes (Basel). 12: PMID: 34440353
5. Blue Cone Monochromatism with Foveal Hypoplasia Caused by the Concomitant Effect of Variants in OPN1LW/OPN1MW and GPR143 Genes.  |  Iarossi, G., et al. 2021. Int J Mol Sci. 22: PMID: 34445325
6. Gene Therapy in Opn1mw-/-/Opn1sw-/- Mice and Implications for Blue Cone Monochromacy Patients with Deletion Mutations.  |  Ma, X., et al. 2022. Hum Gene Ther. 33: 708-718. PMID: 35272502
7. Novel OPN1LW/OPN1MW Exon 3 Haplotype-Associated Splicing Defect in Patients with X-Linked Cone Dysfunction.  |  Stingl, K., et al. 2022. Int J Mol Sci. 23: PMID: 35743313
8. The landscape of submicroscopic structural variants at the OPN1LW/OPN1MW gene cluster on Xq28 underlying blue cone monochromacy.  |  Wissinger, B., et al. 2022. Proc Natl Acad Sci U S A. 119: e2115538119. PMID: 35759666
9. Diagnostic analysis of the highly complex OPN1LW/OPN1MW gene cluster using long-read sequencing and MLPA.  |  Haer-Wigman, L., et al. 2022. NPJ Genom Med. 7: 65. PMID: 36351915
10. Pitfalls in the genetic testing of the OPN1LW-OPN1MW gene cluster in human subjects.  |  Wissinger, B., et al. 2024. NPJ Genom Med. 9: 28. PMID: 38704370