OMG Antibody (E-8): sc-271704

OMG Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects OMG protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-OMG antibody (E-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Oligodendrocyte myelin glycoprotein (OMG, OMgp) plays a crucial role in the development and maintenance of the adult central nervous system (CNS) as a glycosylphosphatidylinositol-anchored protein expressed by neurons and oligodendrocytes. OMG is primarily located in the myelin sheath, where OMG is essential for proper formation and maintenance of this structure, which insulates nerve fibers and facilitates efficient signal transmission. OMG′s presence in the myelin sheath is vital for CNS integrity, as OMG helps regulate interactions between oligodendrocytes and axons, influencing myelination and neuronal health. Furthermore, OMG′s interaction with the Nogo receptor is significant, as OMG inhibits neurite outgrowth, which is critical for preventing excessive neuronal regeneration in the adult CNS. This function is mediated by OMG′s leucine-rich repeat domain, a highly conserved region that is integral to OMG′s role in cell proliferation and myelin sheath maintenance. With diverse applications and essential biological functions, OMG monoclonal antibody (E-8) serves as a valuable tool for researchers studying myelination and neuronal development.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

OMG Antibody (E-8) References:

1. Quantitative analysis of NF1 and OMGP gene transcripts in sporadic gliomas, sporadic meningiomas and neurofibromatosis type 1-associated plexiform neurofibromas.  |  Peters, N., et al. 1999. Acta Neuropathol. 97: 547-51. PMID: 10378372
2. Oligodendrocyte-myelin glycoprotein (OMgp) is an inhibitor of neurite outgrowth.  |  Kottis, V., et al. 2002. J Neurochem. 82: 1566-9. PMID: 12354307
3. P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp.  |  Wang, KC., et al. 2002. Nature. 420: 74-8. PMID: 12422217
4. Oligodendrocyte myelin glycoprotein (OMgp): evolution, structure and function.  |  Vourc'h, P. and Andres, C. 2004. Brain Res Brain Res Rev. 45: 115-24. PMID: 15145622
5. A structurally available encephalitogenic epitope of myelin oligodendrocyte glycoprotein specifically induces a diversified pathogenic autoimmune response.  |  Bischof, F., et al. 2004. J Immunol. 173: 600-6. PMID: 15210822
6. Blockade of Nogo-66, myelin-associated glycoprotein, and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal sprouting and recovery after spinal injury.  |  Li, S., et al. 2004. J Neurosci. 24: 10511-20. PMID: 15548666
7. Signaling cascades activated upon antibody cross-linking of myelin oligodendrocyte glycoprotein: potential implications for multiple sclerosis.  |  Marta, CB., et al. 2005. J Biol Chem. 280: 8985-93. PMID: 15634682
8. Prevention of experimental autoimmune encephalomyelitis by transfer of embryonic stem cell-derived dendritic cells expressing myelin oligodendrocyte glycoprotein peptide along with TRAIL or programmed death-1 ligand.  |  Hirata, S., et al. 2005. J Immunol. 174: 1888-97. PMID: 15699115
9. The OMgp gene, a second growth suppressor within the NF1 gene.  |  Habib, AA., et al. 1998. Oncogene. 16: 1525-31. PMID: 9569019

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OMG Antibody (E-8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-OMG Antibody (E-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OMG Antibody (E-8) Specifications

Alternate Product Name: OMG

Product Clone Name: E-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 195-416

Epitope Target: OMG

Epitope Species: human

Product Reactivity/Detection: OMG

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for OMG Antibody (E-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin