oligophrenin-1 Antibody (A-12): sc-374330
- oligophrenin-1 Antibody (A-12) is a mouse monoclonal IgG1 κ oligophrenin-1 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 775-802 at the C-terminus of oligophrenin-1 of human origin
- oligophrenin-1 Antibody (A-12) is recommended for detection of oligophrenin-1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and equine and bovine
- Anti-oligophrenin-1 Antibody (A-12) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for oligophrenin-1 Antibody (A-12) for WB applications. This reagent is now offered in a bundle with oligophrenin-1 Antibody (A-12) (see ordering information below).
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oligophrenin-1 Antibody (A-12) is a mouse monoclonal IgG1 kappa light chain antibody that detects oligophrenin-1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-oligophrenin-1 antibody (A-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. oligophrenin-1 plays a crucial role as a RhoGAP protein, which is essential for regulating the activity of Rho GTPases involved in critical cellular processes such as cell migration, morphogenesis, and axon outgrowth. By stimulating the hydrolysis of GTP bound to Rho subfamily members, oligophrenin-1 helps to modulate signaling pathways that are vital for proper neuronal development and function. The ability of oligophrenin-1 to influence these pathways underscores its importance in both normal physiological processes and potential pathological conditions, such as neurodevelopmental disorders. With versatile applications and significance in cellular dynamics, oligophrenin-1 monoclonal antibody (A-12) serves as an invaluable tool for researchers studying the intricate mechanisms of cell signaling and development.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
oligophrenin-1 Antibody (A-12) References:
- Oligophrenin-1, a Rho GTPase-activating protein (RhoGAP) involved in X-linked mental retardation, is expressed in the enteric nervous system. | Xiao, J., et al. 2003. Anat Rec A Discov Mol Cell Evol Biol. 273: 671-6. PMID: 12845702
- Molecular cloning of cDNAs encoding the GAP-associated protein p190: implications for a signaling pathway from ras to the nucleus. | Settleman, J., et al. 1992. Cell. 69: 539-49. PMID: 1581965
- The GTPase superfamily: a conserved switch for diverse cell functions. | Bourne, HR., et al. 1990. Nature. 348: 125-32. PMID: 2122258
- A guide to low molecular weight GTPases. | Sanders, DA. 1990. Cell Growth Differ. 1: 251-8. PMID: 2150754
- A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbα. | Valnegri, P., et al. 2011. Nat Neurosci. 14: 1293-301. PMID: 21874017
- Oligophrenin-1 is associated with cell adhesion and migration in prostate cancer. | Goto, K., et al. 2014. Pathobiology. 81: 190-8. PMID: 25170626
- Oligophrenin-1 Connects Exocytotic Fusion to Compensatory Endocytosis in Neuroendocrine Cells. | Houy, S., et al. 2015. J Neurosci. 35: 11045-55. PMID: 26245966
- A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. | Trahey, M. and McCormick, F. 1987. Science. 238: 542-5. PMID: 2821624
- The intellectual disability protein Oligophrenin-1 controls astrocyte morphology and migration. | Pillet, LE., et al. 2020. Glia. 68: 1729-1742. PMID: 32073702
- ras genes. | Barbacid, M. 1987. Annu Rev Biochem. 56: 779-827. PMID: 3304147
- Oligophrenin-1 moderates behavioral responses to stress by regulating parvalbumin interneuron activity in the medial prefrontal cortex. | Wang, M., et al. 2021. Neuron. 109: 1636-1656.e8. PMID: 33831348
- Oligophrenin 1 encodes a rho-GAP protein involved in X-linked mental retardation. | Billuart, P., et al. 1998. Pathol Biol (Paris). 46: 678. PMID: 9885813
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
oligophrenin-1 Antibody (A-12) | sc-374330 | 200 µg/ml | $322.00 | |||
oligophrenin-1 Antibody (A-12): m-IgG Fc BP-HRP Bundle | sc-525953 | 200 µg Ab; 10 µg BP | $361.00 | |||
oligophrenin-1 Antibody (A-12) AC | sc-374330 AC | 500 µg/ml, 25% agarose | $424.00 | |||
oligophrenin-1 Antibody (A-12) HRP | sc-374330 HRP | 200 µg/ml | $322.00 | |||
oligophrenin-1 Antibody (A-12) FITC | sc-374330 FITC | 200 µg/ml | $336.00 | |||
oligophrenin-1 Antibody (A-12) PE | sc-374330 PE | 200 µg/ml | $349.00 | |||
oligophrenin-1 Antibody (A-12) Alexa Fluor® 488 | sc-374330 AF488 | 200 µg/ml | $364.00 | |||
oligophrenin-1 Antibody (A-12) Alexa Fluor® 546 | sc-374330 AF546 | 200 µg/ml | $364.00 | |||
oligophrenin-1 Antibody (A-12) Alexa Fluor® 594 | sc-374330 AF594 | 200 µg/ml | $364.00 | |||
oligophrenin-1 Antibody (A-12) Alexa Fluor® 647 | sc-374330 AF647 | 200 µg/ml | $364.00 | |||
oligophrenin-1 Antibody (A-12) Alexa Fluor® 680 | sc-374330 AF680 | 200 µg/ml | $364.00 | |||
oligophrenin-1 Antibody (A-12) Alexa Fluor® 790 | sc-374330 AF790 | 200 µg/ml | $364.00 | |||
oligophrenin-1 (A-12) Neutralizing Peptide | sc-374330 P | 100 µg/0.5 ml | $69.00 |