OLIG2 Antibody (B-5): sc-518069
- OLIG2 Antibody (B-5) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 6-30 near the N-terminus of OLIG2 of mouse origin
- recommended for detection of OLIG2 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for OLIG2 Antibody (B-5) for WB applications. This reagent is now offered in a bundle with OLIG2 Antibody (B-5) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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OLIG2 Antibody (B-5) is a mouse monoclonal IgG3 antibody that detects OLIG2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OLIG2 plays a crucial role in the development of oligodendrocytes, which are essential for the formation of myelin sheaths that insulate nerve fibers, thereby facilitating efficient signal transmission in the nervous system. The proper functioning of OLIG2 is vital for maintaining the health of the central nervous system, as OLIG2 dysregulation has been implicated in various neurological disorders and glial tumors. Notably, OLIG2 is predominantly expressed in oligodendroglioma, a type of brain tumor, while being nearly absent in astrocytomas, making OLIG2 a potential molecular marker for diagnosing and understanding the progression of these malignancies. OLIG2′s ability to interact with other transcription factors, such as Nkx-2.2, further underscores OLIG2′s importance in neuronal patterning and cell fate determination during embryonic development. With high specificity and versatility, anti-OLIG2 antibody (B-5) is an invaluable tool for researchers investigating oligodendrocyte biology and related pathologies.
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OLIG2 Antibody (B-5) References:
- Olig2 regulates Purkinje cell generation in the early developing mouse cerebellum. | Ju, J., et al. 2016. Sci Rep. 6: 30711. PMID: 27469598
- Olig2 SUMOylation protects against genotoxic damage response by antagonizing p53 gene targeting. | Liu, H., et al. 2020. Cell Death Differ. 27: 3146-3161. PMID: 32483381
- Region-specific distribution of Olig2-expressing astrocytes in adult mouse brain and spinal cord. | Wang, H., et al. 2021. Mol Brain. 14: 36. PMID: 33618751
- One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2. | Chanoumidou, K., et al. 2021. Stem Cell Reports. 16: 771-783. PMID: 33770499
- Olig2 knockdown alleviates hypoxic-ischemic brain damage in newborn rats. | Yang, LJ. and Cui, H. 2021. Histol Histopathol. 36: 675-684. PMID: 34013967
- OLIG2 regulates lncRNAs and its own expression during oligodendrocyte lineage formation. | Wei, H., et al. 2021. BMC Biol. 19: 132. PMID: 34172044
- The Epigenetic Regulation of OLIG2 by Histone Demethylase KDM6B in Glioma Cells. | Sui, A., et al. 2022. J Mol Neurosci. 72: 939-946. PMID: 35132566
- c-Abl-induced Olig2 phosphorylation regulates the proliferation of oligodendrocyte precursor cells. | Zhang, J., et al. 2022. Glia. 70: 1084-1099. PMID: 35156232
- OLIG2 is an in vivo bookmarking transcription factor in the developing neural tube in mouse. | Hayashi, S., et al. 2023. J Neurochem. 165: 303-317. PMID: 36547371
- CELF2 Sustains a Proliferating/OLIG2+ Glioblastoma Cell Phenotype via the Epigenetic Repression of SOX3. | Turchi, L., et al. 2023. Cancers (Basel). 15: PMID: 37894405
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OLIG2 Antibody (B-5) | sc-518069 | 200 µg/ml | $322.00 | |||
OLIG2 Antibody (B-5): m-IgGκ BP-HRP Bundle | sc-525349 | 200 µg Ab, 40 µg BP | $361.00 |