OLIG1 Antibody (H-6): sc-374294

OLIG1 Antibody (H-6) is a mouse monoclonal IgG2a antibody that detects OLIG1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OLIG1 is a member of the oligodendrocyte lineage-specific basic helix-loop-helix (OLIG) family of transcription factors, which play a crucial role in the regulation of oligodendrogenesis, particularly in the development of oligodendrocytes in the nervous system. OLIG1 is predominantly expressed in nervous tissue, where anti-OLIG1 antibody (H-6) detects key regulatory functions during the formation of oligodendrocytes, essential for myelination and proper neuronal function. Notably, OLIG1 interacts with the Nkx-2.2 homeodomain protein, which is vital for ventral neuronal patterning in the embryonic neural tube, thereby influencing the differentiation of various neuronal cell types. OLIG1 expression, along with OLIG2, is significantly elevated in oligodendroglioma, a type of brain tumor, while being nearly absent in astrocytomas, making OLIG1 a potential molecular marker for diagnosing and understanding human glial brain tumors, which are the most prevalent primary malignancies of the brain. OLIG1 monoclonal antibody (H-6) serves as an invaluable tool for researchers studying oligodendrocyte biology and related pathologies.

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OLIG1 Antibody (H-6) References:

1. Expression of the oligodendroglial lineage-associated markers Olig1 and Olig2 in different types of human gliomas.  |  Ohnishi, A., et al. 2003. J Neuropathol Exp Neurol. 62: 1052-9. PMID: 14575240
2. Analysis of the bHLH transcription factors Olig1 and Olig2 in brain tumors.  |  Aguirre-Cruz, L., et al. 2004. J Neurooncol. 67: 265-71. PMID: 15164981
3. Transient expression of Olig1 initiates the differentiation of neural stem cells into oligodendrocyte progenitor cells.  |  Balasubramaniyan, V., et al. 2004. Stem Cells. 22: 878-82. PMID: 15536179
4. Progesterone attenuates neurological behavioral deficits of experimental autoimmune encephalomyelitis through remyelination with nucleus-sublocalized Olig1 protein.  |  Yu, HJ., et al. 2010. Neurosci Lett. 476: 42-5. PMID: 20381586
5. Delayed onset of experimental autoimmune encephalomyelitis in Olig1 deficient mice.  |  Guo, X., et al. 2010. PLoS One. 5: PMID: 20927333
6. Olig1 is expressed in human oligodendrocytes during maturation and regeneration.  |  Othman, A., et al. 2011. Glia. 59: 914-26. PMID: 21446039
7. Differential and cooperative actions of Olig1 and Olig2 transcription factors on immature proliferating cells after contusive spinal cord injury.  |  Kim, HM., et al. 2011. Glia. 59: 1094-106. PMID: 21538562
8. Effect of OLIG1 on the development of oligodendrocytes and myelination in a neonatal rat PVL model induced by hypoxia-ischemia.  |  Cheng, T., et al. 2015. Mol Med Rep. 11: 2379-86. PMID: 25435330
9. Effects of the transcription factor Olig1 on the differentiation and remyelination of oligodendrocyte precursor cells after focal cerebral ischemia in rats.  |  Zhao, H., et al. 2019. Mol Med Rep. 20: 4603-4611. PMID: 31702031
10. Chromosome Translocation t(14;21)(q11;q22) Activates Both OLIG1 and OLIG2 in Pediatric T-cell Lymphoblastic Malignancies and May Signify Adverse Prognosis.  |  Panagopoulos, I., et al. 2020. Cancer Genomics Proteomics. 17: 41-48. PMID: 31882550

The preferred OLIG1 antibody is OLIG1 Antibody (G-3): sc-166256.