OLIG1 Antibody (B-5): sc-166327

OLIG1 Antibody (B-5) is a mouse monoclonal IgG2a antibody that detects OLIG1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OLIG1 is a member of the oligodendrocyte lineage-specific basic helix-loop-helix (OLIG) family of transcription factors, which play a crucial role in the regulation of oligodendrogenesis, particularly in the development of oligodendrocytes in the nervous system. OLIG1 is predominantly expressed in nervous tissue, where anti-OLIG1 antibody (B-5) detects key regulatory functions during the formation of oligodendrocytes, essential for myelination and proper neuronal function. Notably, OLIG1 interacts with the Nkx-2.2 homeodomain protein, which is vital for ventral neuronal patterning in the embryonic neural tube, thereby influencing the differentiation of various neuronal cell types. OLIG1 expression, along with OLIG2, is significantly elevated in oligodendroglioma, a type of brain tumor, while being nearly absent in astrocytomas, highlighting OLIG1′s potential as a molecular marker for glial brain tumors, which are the most prevalent primary malignancies in the human brain. OLIG1 (B-5) antibody serves as an invaluable tool for researchers investigating oligodendrocyte biology and related pathologies.

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OLIG1 Antibody (B-5) References:

1. Ectopic expression of Olig1 promotes oligodendrocyte formation and reduces neuronal survival in developing mouse cortex.  |  Lu, QR., et al. 2001. Nat Neurosci. 4: 973-4. PMID: 11574831
2. The bHLH transcription factors OLIG2 and OLIG1 couple neuronal and glial subtype specification.  |  Zhou, Q. and Anderson, DJ. 2002. Cell. 109: 61-73. PMID: 11955447
3. Immunolocalization of the oligodendrocyte transcription factor 1 (Olig1) in brain tumors.  |  Azzarelli, B., et al. 2004. J Neuropathol Exp Neurol. 63: 170-9. PMID: 14989603
4. Analysis of the bHLH transcription factors Olig1 and Olig2 in brain tumors.  |  Aguirre-Cruz, L., et al. 2004. J Neurooncol. 67: 265-71. PMID: 15164981
5. bHLH transcription factor Olig1 is required to repair demyelinated lesions in the CNS.  |  Arnett, HA., et al. 2004. Science. 306: 2111-5. PMID: 15604411
6. Myelinogenesis and axonal recognition by oligodendrocytes in brain are uncoupled in Olig1-null mice.  |  Xin, M., et al. 2005. J Neurosci. 25: 1354-65. PMID: 15703389
7. Delayed onset of experimental autoimmune encephalomyelitis in Olig1 deficient mice.  |  Guo, X., et al. 2010. PLoS One. 5: PMID: 20927333
8. Differential and cooperative actions of Olig1 and Olig2 transcription factors on immature proliferating cells after contusive spinal cord injury.  |  Kim, HM., et al. 2011. Glia. 59: 1094-106. PMID: 21538562
9. Effect of OLIG1 on the development of oligodendrocytes and myelination in a neonatal rat PVL model induced by hypoxia-ischemia.  |  Cheng, T., et al. 2015. Mol Med Rep. 11: 2379-86. PMID: 25435330
10. Effects of the transcription factor Olig1 on the differentiation and remyelination of oligodendrocyte precursor cells after focal cerebral ischemia in rats.  |  Zhao, H., et al. 2019. Mol Med Rep. 20: 4603-4611. PMID: 31702031

The preferred OLIG1 antibody is OLIG1 Antibody (G-3): sc-166256.