Molecular structure of OGT 2115, CAS Number: 853929-59-6
OGT 2115 (CAS 853929-59-6)
See product citations (2)
Alternate Names:
(E)-2-(2-(4-(3-(4-bromophenyl)acrylamido)-3-fluorophenyl)benzo[d]oxazol-5-yl)acetic acid
Application:
OGT 2115 is a potent, cell-permeable, and orally active antiangiogenic heparanase inhibitor with an IC50 of 0.4 µM.
CAS Number:
853929-59-6
Molecular Weight:
495.30
Molecular Formula:
C24H16BrFN2O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Available in US only.
Available in US only.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
OGT 2115 inhibits heparanase while displaying no major inhibition of human cytocrhome P450 isoenzymes. OGT 2115 displays antiangiogenic propertis in vitro. OGT 2115 has an IC50 value of 0.4 μM. OGT 2115 can suppress metastasis induced by endoplasmic reticulum (ER) stress in breast cancer cells. In prostate cancer models, OGT 2115 may act to induce apoptosis in cancer cells through the downregulation of the myeloid cell leukemia-1 (MCL-1) protein.
OGT 2115 (CAS 853929-59-6) References
- Furanyl-1,3-thiazol-2-yl and benzoxazol-5-yl acetic acid derivatives: novel classes of heparanase inhibitor. | Courtney, SM., et al. 2005. Bioorg Med Chem Lett. 15: 2295-9. PMID: 15837312
- Heparanase: a target for drug discovery in cancer and inflammation. | McKenzie, EA. 2007. Br J Pharmacol. 151: 1-14. PMID: 17339837
- Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1. | Agelidis, AM., et al. 2017. Cell Rep. 20: 439-450. PMID: 28700944
- Dengue virus NS1 cytokine-independent vascular leak is dependent on endothelial glycocalyx components. | Glasner, DR., et al. 2017. PLoS Pathog. 13: e1006673. PMID: 29121099
- Anti-angiogenic drugs: direct anti-cancer agents with mitochondrial mechanisms of action. | Quayle, LA., et al. 2017. Oncotarget. 8: 88670-88688. PMID: 29179466
- Macrophage migration inhibitory factor is critical for dengue NS1-induced endothelial glycocalyx degradation and hyperpermeability. | Chen, HR., et al. 2018. PLoS Pathog. 14: e1007033. PMID: 29702687
- Host Enzymes Heparanase and Cathepsin L Promote Herpes Simplex Virus 2 Release from Cells. | Hopkins, J., et al. 2018. J Virol. 92: PMID: 30232188
- Heparanase regulation of sFLT-1 release in trophoblasts in vitro. | Eddy, AC., et al. 2019. Placenta. 85: 63-68. PMID: 31327483
- Heparanase-2 protects from LPS-mediated endothelial injury by inhibiting TLR4 signalling. | Kiyan, Y., et al. 2019. Sci Rep. 9: 13591. PMID: 31537875
- Current and Emerging Therapies for Ocular Herpes Simplex Virus Type-1 Infections. | Koganti, R., et al. 2019. Microorganisms. 7: PMID: 31658632
- Induction of heparanase via IL-10 correlates with a high infiltration of CD163+ M2-type tumor-associated macrophages in inflammatory breast carcinomas. | El-Nadi, M., et al. 2020. Matrix Biol Plus. 6-7: 100030. PMID: 33543027
- A Marine λ-Oligocarrageenan Inhibits Migratory and Invasive Ability of MDA-MB-231 Human Breast Cancer Cells through Actions on Heparanase Metabolism and MMP-14/MMP-2 Axis. | Cousin, R., et al. 2021. Mar Drugs. 19: PMID: 34677445
- Opposing Roles of IGFBP-3 and Heparanase in Regulating A549 Lung Cancer Cell Survival. | Al Khashali, H., et al. 2022. Cells. 11: PMID: 36428962
- Pathophysiology of reinfection by exogenous HSV-1 is driven by heparanase dysfunction. | Suryawanshi, RK., et al. 2023. Sci Adv. 9: eadf3977. PMID: 37115924
Inhibitor of:
Angiogenesis, HPA1, and ITIH (Inter-alpha-trypsin inhibitor).Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OGT 2115, 1 mg | sc-204144 | 1 mg | $98.00 | |||
| US: Only available in the US | ||||||