Odf2 Antibody (G-2): sc-393881

Odf2 Antibody (G-2) is a mouse monoclonal IgG1 antibody that detects Odf2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Odf2 antibody (G-2) plays a crucial role in studying the outer dense fibers (ODF) and fibrous sheath (FS) of mammalian sperm tails, which are essential for maintaining the structural integrity and elastic properties of the flagellum. The ODFs, located on the exterior of the axoneme, are composed of a complex array of proteins, including Odf1, Odf2, and Odf3, which are predominantly expressed during spermiogenesis. Notably, Odf2 protein is involved in the assembly of these fibers through interactions with Odf1, utilizing leucine zipper motifs that facilitate protein-protein interactions. The significance of Odf2 extends beyond structural roles, as mutations or dysfunctions in these proteins have been implicated in male infertility due to compromised flagellar function. The human Odf2 gene is located on chromosome 9q34, and expression is restricted to the testis, highlighting its specialized function in reproductive biology. Odf2 monoclonal antibody (G-2) enables researchers to gain insights into the molecular mechanisms underlying sperm motility and fertility, making this tool invaluable in reproductive health studies.

The preferred Odf2 antibody is Odf2 Antibody (G-8): sc-365874.