OCT6 Antibody (H-6): sc-390056
- OCT6 Antibody (H-6) is a mouse monoclonal IgG1 κ OCT6 antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 33-145 mapping near the C-terminus of OCT6 of human origin
- OCT6 Antibody (H-6) is recommended for detection of OCT6 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-OCT6 Antibody (H-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for OCT6 Antibody (H-6) for WB applications. These reagents are now offered in bundles with OCT6 Antibody (H-6) (see ordering information below).
OCT6 Antibody (H-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects OCT6 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-OCT6 antibody (H-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. OCT6 (H-6) antibody recognizes a member of the organic cation transporter family that plays a crucial role in the transport of endogenous amines and cationic drugs across cell membranes, which is vital for maintaining cellular homeostasis and drug metabolism. OCT6 is predominantly expressed in the testis and fetal liver, as well as in human hematopoietic tissues, including CD34+ cells and various leukemias, highlighting OCT6′s potential as a therapeutic target in leukemia treatment. A 12-transmembrane-domain configuration and large extracellular hydrophilic loop characterize OCT6′s structure, which is essential for facilitating selective transport of cationic substances, thereby influencing pharmacokinetics and therapeutic agent efficacy.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
OCT6 Antibody (H-6) References:
- Molecular and functional characteristics of cloned human organic cation transporters. | Dresser, MJ., et al. 1999. Pharm Biotechnol. 12: 441-69. PMID: 10742984
- Identification of OCT6 as a novel organic cation transporter preferentially expressed in hematopoietic cells and leukemias. | Gong, S., et al. 2002. Exp Hematol. 30: 1162-9. PMID: 12384147
- Cloning and characterization of two human polyspecific organic cation transporters. | Gorboulev, V., et al. 1997. DNA Cell Biol. 16: 871-81. PMID: 9260930
- Organic cation transporters in intestine, kidney, liver, and brain. | Koepsell, H. 1998. Annu Rev Physiol. 60: 243-66. PMID: 9558463
- Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27. | Verhaagh, S., et al. 1999. Genomics. 55: 209-18. PMID: 9933568
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OCT6 Antibody (H-6) | sc-390056 | 200 µg/ml | $316.00 | |||
OCT6 Antibody (H-6): m-IgG Fc BP-HRP Bundle | sc-527614 | 200 µg Ab; 10 µg BP | $354.00 | |||
OCT6 Antibody (H-6): m-IgG1 BP-HRP Bundle | sc-532987 | 200 µg Ab; 20 µg BP | $354.00 | |||
OCT6 Antibody (H-6) AC | sc-390056 AC | 500 µg/ml, 25% agarose | $416.00 | |||
OCT6 Antibody (H-6) HRP | sc-390056 HRP | 200 µg/ml | $316.00 | |||
OCT6 Antibody (H-6) FITC | sc-390056 FITC | 200 µg/ml | $330.00 | |||
OCT6 Antibody (H-6) PE | sc-390056 PE | 200 µg/ml | $343.00 | |||
OCT6 Antibody (H-6) Alexa Fluor® 488 | sc-390056 AF488 | 200 µg/ml | $357.00 | |||
OCT6 Antibody (H-6) Alexa Fluor® 546 | sc-390056 AF546 | 200 µg/ml | $357.00 | |||
OCT6 Antibody (H-6) Alexa Fluor® 594 | sc-390056 AF594 | 200 µg/ml | $357.00 | |||
OCT6 Antibody (H-6) Alexa Fluor® 647 | sc-390056 AF647 | 200 µg/ml | $357.00 | |||
OCT6 Antibody (H-6) Alexa Fluor® 680 | sc-390056 AF680 | 200 µg/ml | $357.00 | |||
OCT6 Antibody (H-6) Alexa Fluor® 790 | sc-390056 AF790 | 200 µg/ml | $357.00 |