OCIAD1 Antibody (E-12): sc-390906

OCIAD1 Antibody (E-12) is a mouse monoclonal IgG2b kappa light chain antibody that detects OCIAD1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-OCIAD1 antibody (E-12) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. OCIAD1, also known as OCIA (ovarian carcinoma immunoreactive antigen), TPA018, or ASRIJ, is a 245 amino acid endosomal protein characterized by the presence of one OCIA domain and is a member of the OCIAD1 family. OCIAD1 plays a crucial role in cellular processes, particularly in the endosomal pathway, which is essential for the sorting and trafficking of proteins within cells. Proper functioning of OCIAD1 is vital for maintaining cellular homeostasis and regulating immune responses, making OCIAD1 a significant target for research in cancer and other diseases. OCIAD1 exists in two alternatively spliced isoforms, with isoform A found in tissues such as the prostate, brain, mammary gland, testis, placenta, and ovary, while isoform B is primarily localized to the central nervous system. The gene encoding OCIAD1 is located on human chromosome 4, which is associated with various genetic disorders, including Huntington′s disease, Ellis-van Creveld syndrome, methylmalonic acidemia, and polycystic kidney disease, highlighting OCIAD1′s importance in both health and disease.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

OCIAD1 Antibody (E-12) References:

1. Exclusion of the Ellis-van Creveld region on chromosome 4p16 in some families with asphyxiating thoracic dystrophy and short-rib polydactyly syndromes.  |  Krakow, D., et al. 2000. Eur J Hum Genet. 8: 645-8. PMID: 10951528
2. Phenotypic variations of orpk mutation and chromosomal localization of modifiers influencing kidney phenotype.  |  Sommardahl, C., et al. 2001. Physiol Genomics. 7: 127-34. PMID: 11773599
3. Identification of the gene responsible for the cblA complementation group of vitamin B12-responsive methylmalonic acidemia based on analysis of prokaryotic gene arrangements.  |  Dobson, CM., et al. 2002. Proc Natl Acad Sci U S A. 99: 15554-9. PMID: 12438653
4. Ovarian cancer immuno-reactive antigen domain containing 1 (OCIAD1), a key player in ovarian cancer cell adhesion.  |  Sengupta, S., et al. 2008. Gynecol Oncol. 109: 226-33. PMID: 18328549
5. OCIAD1 Controls Electron Transport Chain Complex I Activity to Regulate Energy Metabolism in Human Pluripotent Stem Cells.  |  Shetty, DK., et al. 2018. Stem Cell Reports. 11: 128-141. PMID: 29937147
6. Asrij/OCIAD1 suppresses CSN5-mediated p53 degradation and maintains mouse hematopoietic stem cell quiescence.  |  Sinha, S., et al. 2019. Blood. 133: 2385-2400. PMID: 30952670
7. OCIAD1 promoted pancreatic ductal adenocarcinoma migration by regulating ATM.  |  Ji, W., et al. 2019. Pancreatology. 19: 751-759. PMID: 31221523
8. OCIAD1 contributes to neurodegeneration in Alzheimer's disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages.  |  Li, X., et al. 2020. EBioMedicine. 51: 102569. PMID: 31931285
9. OCIAD1 and prohibitins regulate the stability of the TIM23 protein translocase.  |  Elancheliyan, P., et al. 2024. Cell Rep. 43: 115038. PMID: 39630581
10. Huntingtin is ubiquitinated and interacts with a specific ubiquitin-conjugating enzyme.  |  Kalchman, MA., et al. 1996. J Biol Chem. 271: 19385-94. PMID: 8702625
11. Autosomal dominant postaxial polydactyly, nail dystrophy, and dental abnormalities map to chromosome 4p16, in the region containing the Ellis-van Creveld syndrome locus.  |  Howard, TD., et al. 1997. Am J Hum Genet. 61: 1405-12. PMID: 9399901
12. Huntingtin protein colocalizes with lesions of neurodegenerative diseases: An investigation in Huntington's, Alzheimer's, and Pick's diseases.  |  Singhrao, SK., et al. 1998. Exp Neurol. 150: 213-22. PMID: 9527890

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-OCIAD1 Antibody (E-12) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-OCIAD1 Antibody (E-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

OCIAD1 Antibody (E-12) Specifications

Alternate Product Name: OCIAD1

Product Clone Name: E-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 2-39

Epitope Target: OCIAD1

Epitope Species: human

Product Reactivity/Detection: OCIAD1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: equine, canine and bovine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for OCIAD1 Antibody (E-12): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin