OB-cadherin Antibody (F-3): sc-365867
- OB-cadherin Antibody (F-3) is a mouse monoclonal IgG1 OB-cadherin antibody, cited in 4 publications, provided at 200 µg/ml
- raised against amino acids 681-730 mapping within a C-terminal cytoplasmic domain of OB-cadherin of human origin
- OB-cadherin Antibody (F-3) is recommended for detection of OB-cadherin (cadherin-11) of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-OB-cadherin Antibody (F-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for OB-cadherin Antibody (F-3) for WB applications. This reagent is now offered in a bundle with OB-cadherin Antibody (F-3) (see ordering information below).
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SEE ALSO...
OB-cadherin Antibody (F-3) is a mouse monoclonal IgG1 antibody that detects OB-cadherin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). OB-cadherin Antibody (F-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. The cadherin family, to which OB-cadherin belongs, consists of calcium-dependent adhesion molecules that play a vital role in cell-cell adhesion, thereby maintaining tissue integrity and facilitating morphogenetic processes. OB-cadherin, also known as osteoblast-cadherin, cadherin-11, or OSF-4, exists in two isoforms: OB-cadherin-1 and OB-cadherin-2, with the latter featuring a truncated cytoplasmic domain that lacks amino acids 694-796. Both isoforms are predominantly expressed in osteoblastic cell lines, with lower levels detected in tissues such as the lungs, testis, and brain. OB-cadherin′s significance extends beyond structural roles; OB-cadherin is also involved in signaling pathways that regulate osteoblast differentiation and function, making OB-cadherin a critical target for studies related to bone development and pathology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
OB-cadherin Antibody (F-3) References:
- N-cadherin and cadherin 11 modulate postnatal bone growth and osteoblast differentiation by distinct mechanisms. | Di Benedetto, A., et al. 2010. J Cell Sci. 123: 2640-8. PMID: 20605916
- Cadherin-11 as a therapeutic target in chronic, inflammatory rheumatic diseases. | Sfikakis, PP., et al. 2017. Clin Immunol. 176: 107-113. PMID: 28115292
- Cadherin-11 Is a Regulator of Intestinal Fibrosis. | Franzè, E., et al. 2020. J Crohns Colitis. 14: 406-417. PMID: 31504344
- Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice. | Peran, I., et al. 2021. Gastroenterology. 160: 1359-1372.e13. PMID: 33307028
- Cadherin-11 Regulates Macrophage Development and Function. | To, S., et al. 2022. Front Immunol. 13: 795337. PMID: 35211116
- Cadherin-11 and Its Role in Tissue Fibrosis. | Chavula, T., et al. 2023. Cells Tissues Organs. 212: 293-303. PMID: 35662129
- Loss of Cadherin-11 in pancreatic ductal adenocarcinoma alters tumor-immune microenvironment. | Sebastian, A., et al. 2023. Front Oncol. 13: 1286861. PMID: 37954069
- CADHERIN-11 regulation of myeloid phagocytes and autoimmune inflammation in murine lupus. | Chavula, T., et al. 2024. J Autoimmun. 145: 103197. PMID: 38447248
- Desmosomal cadherins: another growing multigene family of adhesion molecules. | Koch, PJ. and Franke, WW. 1994. Curr Opin Cell Biol. 6: 682-7. PMID: 7833048
- Cadherins and catenins: interactions and functions in embryonic development. | Ranscht, B. 1994. Curr Opin Cell Biol. 6: 740-6. PMID: 7833053
- Spatial and temporal relationships between cadherins and PECAM-1 in cell-cell junctions of human endothelial cells. | Ayalon, O., et al. 1994. J Cell Biol. 126: 247-58. PMID: 8027182
- Morphogenetic roles of classic cadherins. | Takeichi, M. 1995. Curr Opin Cell Biol. 7: 619-27. PMID: 8573335
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
OB-cadherin Antibody (F-3) | sc-365867 | 200 µg/ml | $322.00 | |||
OB-cadherin Antibody (F-3): m-IgG Fc BP-HRP Bundle | sc-525903 | 200 µg Ab; 10 µg BP | $361.00 | |||
OB-cadherin Antibody (F-3) AC | sc-365867 AC | 500 µg/ml, 25% agarose | $424.00 | |||
OB-cadherin Antibody (F-3) HRP | sc-365867 HRP | 200 µg/ml | $322.00 | |||
OB-cadherin Antibody (F-3) FITC | sc-365867 FITC | 200 µg/ml | $336.00 | |||
OB-cadherin Antibody (F-3) PE | sc-365867 PE | 200 µg/ml | $349.00 | |||
OB-cadherin Antibody (F-3) Alexa Fluor® 488 | sc-365867 AF488 | 200 µg/ml | $364.00 | |||
OB-cadherin Antibody (F-3) Alexa Fluor® 546 | sc-365867 AF546 | 200 µg/ml | $364.00 | |||
OB-cadherin Antibody (F-3) Alexa Fluor® 594 | sc-365867 AF594 | 200 µg/ml | $364.00 | |||
OB-cadherin Antibody (F-3) Alexa Fluor® 647 | sc-365867 AF647 | 200 µg/ml | $364.00 | |||
OB-cadherin Antibody (F-3) Alexa Fluor® 680 | sc-365867 AF680 | 200 µg/ml | $364.00 | |||
OB-cadherin Antibody (F-3) Alexa Fluor® 790 | sc-365867 AF790 | 200 µg/ml | $364.00 |