Oatp2 Antibody (A-2): sc-376424

Oatp2 Antibody (A-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Oatp2 protein of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-Oatp2 antibody (A-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Oatp2 protein, also known as Slc21a5 or Slco1a4, plays a crucial role in hepatic uptake of organic anions, including cardiac glycosides, which are vital for regulating heart function. Oatp2 is predominantly expressed in liver and brain, facilitating sodium-independent transport of important steroid conjugates such as dehydroepiandrosterone sulfate and estradiol-17-glucuronide. Oatp2 is localized to basolateral membrane of hepatocytes, where Oatp2 is essential for liver′s ability to extract these compounds from bloodstream. Expression of Oatp2 can be influenced by various factors, including inducers like phenobarbital, which enhances liver′s capacity to uptake cardiac glycosides. Oatp2 is involved in transport of taurocholic acid and other significant molecules, including adrenal androgen dehydroepiandrosterone sulfate and cholesterol-lowering drug pravastatin, highlighting Oatp2′s importance in both drug metabolism and physiological processes.

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Oatp2 Antibody (A-2) References:

1. Localization and function of the organic anion-transporting polypeptide Oatp2 in rat liver.  |  Reichel, C., et al. 1999. Gastroenterology. 117: 688-95. PMID: 10464146
2. A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters.  |  Hsiang, B., et al. 1999. J Biol Chem. 274: 37161-8. PMID: 10601278
3. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane.  |  König, J., et al. 2000. Am J Physiol Gastrointest Liver Physiol. 278: G156-64. PMID: 10644574
4. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide.  |  König, J., et al. 2000. J Biol Chem. 275: 23161-8. PMID: 10779507
5. Identification of organic anion transporting polypeptide 4 (Oatp4) as a major full-length isoform of the liver-specific transporter-1 (rlst-1) in rat liver.  |  Cattori, V., et al. 2000. FEBS Lett. 474: 242-5. PMID: 10838093
6. Differential regulation of hepatic bile salt and organic anion transporters in pregnant and postpartum rats and the role of prolactin.  |  Cao, J., et al. 2001. Hepatology. 33: 140-7. PMID: 11124830
7. Functional analysis and androgen-regulated expression of mouse organic anion transporting polypeptide 1 (Oatp1) in the kidney.  |  Isern, J., et al. 2001. Biochim Biophys Acta. 1518: 73-8. PMID: 11267661
8. Differential effects of microsomal enzyme-inducing chemicals on the hepatic expression of rat organic anion transporters, OATP1 and OATP2.  |  Rausch-Derra, LC., et al. 2001. Hepatology. 33: 1469-78. PMID: 11391536
9. Expression of hepatic transporters OATP-C and MRP2 in primary sclerosing cholangitis.  |  Oswald, M., et al. 2001. Liver. 21: 247-53. PMID: 11454187
10. Distribution of organic anion-transporting polypeptide 2 (oatp2) and oatp3 in the rat retina.  |  Ito, A., et al. 2002. Invest Ophthalmol Vis Sci. 43: 858-63. PMID: 11867608
11. Predominant contribution of rat organic anion transporting polypeptide-2 (Oatp2) to hepatic uptake of beta-lactam antibiotics.  |  Nakakariya, M., et al. 2008. Pharm Res. 25: 578-85. PMID: 17891554
12. Organic anion transporting polypeptide 2 transports valproic acid in rat brain microvascular endothelial cells.  |  Guo, Y. and Jiang, L. 2016. Neurol Res. 38: 634-9. PMID: 27156567

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Oatp2 Antibody (A-2) has 6 citations in a variety of scientific publications.

Primary antibodies like Anti-Oatp2 Antibody (A-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Oatp2 Antibody (A-2) Specifications

Alternate Product Name: Oatp2

Product Clone Name: A-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 611-660

Epitope Target: Oatp2

Epitope Species: mouse

Product Reactivity/Detection: Oatp2

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for Oatp2 Antibody (A-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin