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O6-[4-(Aminomethyl)benzyl]guanine (CAS 674799-96-3)
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O6-[4-(Aminomethyl)benzyl]guanine is a compound of particular interest in the field of molecular biology and genetics, as it is structurally related to guanine, one of the four primary nucleobases found in DNA. It is employed as a molecular probe in the study of DNA repair mechanisms, especially in the context of understanding the O6-alkylguanine DNA alkyltransferase (AGT) enzyme′s role, which plays a critical part in the repair of DNA damage caused by alkylating agents. The modified benzyl group attached to the guanine base in this compound allows researchers to investigate the substrate specificity and reaction kinetics of AGT, contributing to a deeper comprehension of cellular responses to genetic damage. Additionally, O6-[4-(Aminomethyl)benzyl]guanine is used as a tool in epigenetic studies to understand the methylation patterns that regulate gene expression and the potential implications of these modifications in various biological processes and conditions.
O6-[4-(Aminomethyl)benzyl]guanine (CAS 674799-96-3) References
- MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation. | Eyster, CA., et al. 2011. Mol Biol Cell. 22: 3218-30. PMID: 21757542
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
O6-[4-(Aminomethyl)benzyl]guanine, 5 mg | sc-208125 | 5 mg | $412.00 |