Molecular structure of O-1821, CAS Number: 35482-50-9
O-1821 (CAS 35482-50-9)
Application:
O-1821 is a cannabidiol analog
CAS Number:
35482-50-9
Molecular Weight:
258.36
Molecular Formula:
C17H22O2
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
O-1821 is a cannabidiol analog with close structural similarity to O-1918 which is a selective antagonist of abnormal cannabidiol at the non-CB1/CB2 endothelial receptor.2 O-1918 does not bind to CB1 or CB2 receptors at concentrations up to 30 µM and inhibits the vasorelaxant effects of abnormal cannabidiol in vitro and in whole animals.2 The biological activity of O-1821 has not been reported.
O-1821 (CAS 35482-50-9) References
- Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors. | Járai, Z., et al. 1999. Proc Natl Acad Sci U S A. 96: 14136-41. PMID: 10570211
- Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. | Offertáler, L., et al. 2003. Mol Pharmacol. 63: 699-705. PMID: 12606780
- TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. | Qin, N., et al. 2008. J Neurosci. 28: 6231-8. PMID: 18550765
- Application of surrogates, indicators, and high-resolution mass spectrometry to evaluate the efficacy of UV processes for attenuation of emerging contaminants in water. | Merel, S., et al. 2015. J Hazard Mater. 282: 75-85. PMID: 25262385
- The cation channel Trpv2 is a new suppressor of arthritis severity, joint damage, and synovial fibroblast invasion. | Laragione, T., et al. 2015. Clin Immunol. 158: 183-92. PMID: 25869297
- Cannabidiol, a novel inverse agonist for GPR12. | Brown, KJ., et al. 2017. Biochem Biophys Res Commun. 493: 451-454. PMID: 28888984
- GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol. | Laun, AS., et al. 2019. Acta Pharmacol Sin. 40: 300-308. PMID: 29941868
- Novel inverse agonists for the orphan G protein-coupled receptor 6. | Laun, AS., et al. 2018. Heliyon. 4: e00933. PMID: 30480157
- Transient Receptor Potential Channel Expression Signatures in Tumor-Derived Endothelial Cells: Functional Roles in Prostate Cancer Angiogenesis. | Bernardini, M., et al. 2019. Cancers (Basel). 11: PMID: 31288452
- The Atypical Cannabinoid Abn-CBD Reduces Inflammation and Protects Liver, Pancreas, and Adipose Tissue in a Mouse Model of Prediabetes and Non-alcoholic Fatty Liver Disease. | Romero-Zerbo, SY., et al. 2020. Front Endocrinol (Lausanne). 11: 103. PMID: 32210914
Inhibitor of:
CB1, and CB2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
O-1821, 1 mg | sc-205417 | 1 mg | $31.00 | |||
O-1821, 5 mg | sc-205417A | 5 mg | $121.00 |