Nup133 Antibody (G-11): sc-515253
- Nup133 Antibody (G-11) is a mouse monoclonal IgG3 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 59-87 near the N-terminus of Nup133 of human origin
- recommended for detection of Nup133 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG3 BP-HRP is the preferred secondary detection reagent for Nup133 Antibody (G-11) for WB applications. This reagent is now offered in a bundle with Nup133 Antibody (G-11) (see ordering information below).
Nup133 Antibody (G-11) is a mouse monoclonal IgG3 antibody that detects nuclear pore complex protein Nup133 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Nup133 antibody (G-11) plays a crucial role in studying nuclear pore complexes (NPCs), which are essential for the regulated transport of macromolecules between the nucleus and cytoplasm. Nup133 (G-11) monoclonal antibody enables research on the Nup160 nuclear pore subcomplex, which includes Nup160, Nup96, and Nup107, and is vital for RNA export, a process critical for gene expression and cellular function. Unique structural features of Nup133, including O-linked N-acetylglucosamine modifications and pentapeptide repeat motifs, contribute to interactions with various nucleoporins and facilitate assembly and stability of the nuclear pore complex. Understanding Nup133 dynamics and interactions helps elucidate mechanisms of nucleocytoplasmic transport and implications in cellular processes and diseases.
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Nup133 Antibody (G-11) References:
- An evolutionarily conserved NPC subcomplex, which redistributes in part to kinetochores in mammalian cells. | Belgareh, N., et al. 2001. J Cell Biol. 154: 1147-60. PMID: 11564755
- A general amphipathic alpha-helical motif for sensing membrane curvature. | Drin, G., et al. 2007. Nat Struct Mol Biol. 14: 138-46. PMID: 17220896
- Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex. | Glavy, JS., et al. 2007. Proc Natl Acad Sci U S A. 104: 3811-6. PMID: 17360435
- Mapping the orientation of nuclear pore proteins in living cells with polarized fluorescence microscopy. | Kampmann, M., et al. 2011. Nat Struct Mol Biol. 18: 643-9. PMID: 21499242
- Human Asunder promotes dynein recruitment and centrosomal tethering to the nucleus at mitotic entry. | Jodoin, JN., et al. 2012. Mol Biol Cell. 23: 4713-24. PMID: 23097494
- Homozygous mutation in NUP107 leads to microcephaly with steroid-resistant nephrotic condition similar to Galloway-Mowat syndrome. | Rosti, RO., et al. 2017. J Med Genet. 54: 399-403. PMID: 28280135
- Roles of Nup133, Nup153 and membrane fenestrations in assembly of the nuclear pore complex at the end of mitosis. | Bilir, Ş., et al. 2019. Genes Cells. 24: 338-353. PMID: 30821042
- NUP133 Controls Nuclear Pore Assembly, Transcriptome Composition, and Cytoskeleton Regulation in Podocytes. | Rogg, M., et al. 2022. Cells. 11: PMID: 35455939
- A nuclear pore complex-associated regulation of SUMOylation in meiosis. | Yang, HJ., et al. 2023. Genes Cells. 28: 188-201. PMID: 36562208
- Steroid-resistant nephrotic syndrome caused by nuclear pore gene NUP133 variation. | Wang, Q., et al. 2023. Clin Genet. 104: 272-274. PMID: 37041680
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nup133 Antibody (G-11) | sc-515253 | 200 µg/ml | $316.00 | |||
Nup133 Antibody (G-11): m-IgG3 BP-HRP Bundle | sc-550530 | 200 µg Ab; 40 µg BP | $354.00 | |||
Nup133 (G-11) Neutralizing Peptide | sc-515253 P | 100 µg/0.5 ml | $68.00 |