nucleoporin p62 Antibody (G-8): sc-166870
- nucleoporin p62 Antibody (G-8) is a mouse monoclonal IgG2a κ, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-20 at the N-terminus of nucleoporin p62 of human origin
- Anti-nucleoporin p62 Antibody (G-8) is recommended for detection of nucleoporin p62 of mouse, rat, human and mink origin by WB, IP, IF, IHC(P) and ELISA
- Anti-nucleoporin p62 Antibody (G-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for nucleoporin p62 Antibody (G-8). This work is in progress.
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nucleoporin p62 Antibody (G-8) is a mouse monoclonal IgG2a kappa light chain antibody that detects nucleoporin p62 of mouse, rat, human, and mink origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-nucleoporin p62 antibody (G-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. nucleoporin p62 plays a critical role in the nuclear transport system, facilitating selective movement of proteins and RNA across the nuclear envelope. Located at the nuclear pore complex, nucleoporin p62 is essential for importing proteins into the nucleus and exporting newly synthesized mRNA, ensuring proper cellular function and gene expression regulation. nucleoporin p62 interacts with other proteins, such as karyopherins and nuclear transport factor 2 (NTF2), highlighting its importance in the transport process; karyopherin α and β work together to recognize and dock substrates at the nuclear pore, while NTF2 enhances nucleoporin p62 functionality by forming a homodimer. nucleoporin p62′s ability to mediate these processes underscores its significance in maintaining cellular homeostasis and responding to various physiological demands.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
nucleoporin p62 Antibody (G-8) References:
- Primary sequence and heterologous expression of nuclear pore glycoprotein p62. | Starr, CM., et al. 1990. J Cell Biol. 110: 1861-71. PMID: 2190987
- SQSTM1/p62 promotes mitochondrial ubiquitination independently of PINK1 and PRKN/parkin in mitophagy. | Yamada, T., et al. 2019. Autophagy. 15: 2012-2018. PMID: 31339428
- Hepatocytic p62 suppresses ductular reaction and tumorigenesis in mouse livers with mTORC1 activation and defective autophagy. | Chao, X., et al. 2022. J Hepatol. 76: 639-651. PMID: 34710483
- OTUD7B deubiquitinates SQSTM1/p62 and promotes IRF3 degradation to regulate antiviral immunity. | Xie, W., et al. 2022. Autophagy. 18: 2288-2302. PMID: 35100065
- TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2. | Yu, T., et al. 2023. Cell Rep. 42: 113231. PMID: 37804507
- CDKL5 regulates p62-mediated selective autophagy and confers protection against neurotropic viruses. | Thinwa, JW., et al. 2024. J Clin Invest. 134: PMID: 37917202
- S-acylation regulates SQSTM1/p62-mediated selective autophagy. | Huang, X., et al. 2024. Autophagy. 20: 1467-1469. PMID: 38124295
- Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction. | Feng, J., et al. 2024. J Transl Med. 22: 161. PMID: 38365674
- Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration. | Jiménez-Loygorri, JI., et al. 2024. Mol Neurodegener. 19: 49. PMID: 38890703
- Analysis of nuclear pore protein p62 glycosylation. | Lubas, WA., et al. 1995. Biochemistry. 34: 1686-94. PMID: 7849028
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
nucleoporin p62 Antibody (G-8) | sc-166870 | 200 µg/ml | $322.00 | |||
nucleoporin p62 Antibody (G-8) AC | sc-166870 AC | 500 µg/ml, 25% agarose | $424.00 | |||
nucleoporin p62 Antibody (G-8) HRP | sc-166870 HRP | 200 µg/ml | $322.00 | |||
nucleoporin p62 Antibody (G-8) FITC | sc-166870 FITC | 200 µg/ml | $336.00 | |||
nucleoporin p62 Antibody (G-8) PE | sc-166870 PE | 200 µg/ml | $349.00 | |||
nucleoporin p62 Antibody (G-8) Alexa Fluor® 488 | sc-166870 AF488 | 200 µg/ml | $364.00 | |||
nucleoporin p62 Antibody (G-8) Alexa Fluor® 546 | sc-166870 AF546 | 200 µg/ml | $364.00 | |||
nucleoporin p62 Antibody (G-8) Alexa Fluor® 594 | sc-166870 AF594 | 200 µg/ml | $364.00 | |||
nucleoporin p62 Antibody (G-8) Alexa Fluor® 647 | sc-166870 AF647 | 200 µg/ml | $364.00 | |||
nucleoporin p62 Antibody (G-8) Alexa Fluor® 680 | sc-166870 AF680 | 200 µg/ml | $364.00 | |||
nucleoporin p62 Antibody (G-8) Alexa Fluor® 790 | sc-166870 AF790 | 200 µg/ml | $364.00 | |||
nucleoporin p62 (G-8) Neutralizing Peptide | sc-166870 P | 100 µg/0.5 ml | $69.00 |