nucleoporin p62 Antibody (C-9): sc-48373

nucleoporin p62 Antibody (C-9) is a mouse monoclonal IgG1 kappa light chain antibody that detects nucleoporin p62 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). anti-nucleoporin p62 antibody (C-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. nucleoporin p62 protein plays a crucial role in the nuclear transport system, facilitating selective movement of proteins and RNA across the nuclear envelope. nucleoporin p62 is located at the nuclear pore complex, where nucleoporin p62 interacts with karyopherin proteins, which are essential for recognizing and docking import substrates. This interaction ensures proteins are accurately transported into the nucleus for functions such as gene expression regulation and DNA repair. nucleoporin p62 is involved in export of nascent mRNA strands, highlighting a dual role in both import and export mechanisms. nucleoporin p62 also interacts with nuclear transport factor 2 (NTF2), which is essential for maintaining cellular homeostasis and regulating gene expression.

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nucleoporin p62 Antibody (C-9) References:

1. Nucleoporin p62 antibodies in a case of mixed connective tissue disease.  |  Kraemer, DM., et al. 2003. Clin Diagn Lab Immunol. 10: 329-31. PMID: 12626463
2. The N-terminal domain of the mammalian nucleoporin p62 interacts with other nucleoporins of the FXFG family during interphase.  |  Stochaj, U., et al. 2006. Exp Cell Res. 312: 2490-9. PMID: 16730000
3. Detection of Autoantibodies Against Nucleoporin p62 in Sera of Patients With Primary Biliary Cholangitis.  |  Bauer, A. and Habior, A. 2019. Ann Lab Med. 39: 291-298. PMID: 30623621
4. Macromolecular interactions in the nucleoporin p62 complex of rat nuclear pores: binding of nucleoporin p54 to the rod domain of p62.  |  Buss, F. and Stewart, M. 1995. J Cell Biol. 128: 251-61. PMID: 7531196
5. Direct interaction of nucleoporin p62 with mRNA during its export from the nucleus.  |  Dargemont, C., et al. 1995. J Cell Sci. 108 (Pt 1): 257-63. PMID: 7738103
6. Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62.  |  Paschal, BM. and Gerace, L. 1995. J Cell Biol. 129: 925-37. PMID: 7744965
7. Protein export from the nucleus requires the GTPase Ran and GTP hydrolysis.  |  Moroianu, J. and Blobel, G. 1995. Proc Natl Acad Sci U S A. 92: 4318-22. PMID: 7753805
8. Previously identified protein of uncertain function is karyopherin alpha and together with karyopherin beta docks import substrate at nuclear pore complexes.  |  Moroianu, J., et al. 1995. Proc Natl Acad Sci U S A. 92: 2008-11. PMID: 7892216
9. Ran binding domains promote the interaction of Ran with p97/beta-karyopherin, linking the docking and translocation steps of nuclear import.  |  Lounsbury, KM., et al. 1996. J Biol Chem. 271: 2357-60. PMID: 8576188
10. The binding site of karyopherin alpha for karyopherin beta overlaps with a nuclear localization sequence.  |  Moroianu, J., et al. 1996. Proc Natl Acad Sci U S A. 93: 6572-6. PMID: 8692858
11. Nuclear protein import: Ran-GTP dissociates the karyopherin alphabeta heterodimer by displacing alpha from an overlapping binding site on beta.  |  Moroianu, J., et al. 1996. Proc Natl Acad Sci U S A. 93: 7059-62. PMID: 8692944
12. An evaluation of sialation of the nucleoporin p62.  |  Fang, B., et al. 1998. Arch Biochem Biophys. 357: 95-100. PMID: 9721187

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-nucleoporin p62 Antibody (C-9) has 17 citations in a variety of scientific publications.

Primary antibodies like Anti-nucleoporin p62 Antibody (C-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

nucleoporin p62 Antibody (C-9) Specifications

Alternate Product Name: nucleoporin p62

Product Clone Name: C-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 401-522

Epitope Target: nucleoporin p62

Epitope Species: human

Product Reactivity/Detection: nucleoporin p62

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 17 citations in various scientific publications

Available Conjugates/Forms for nucleoporin p62 Antibody (C-9): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin