NT-3 Antibody (A-4): sc-518099
- NT-3 Antibody (A-4) is a mouse monoclonal IgG1 κ NT-3 antibody, cited in 3 publications, provided at 200 µg/ml
- raised against amino acids 139-257 of NT-3 of human origin
- recommended for detection of NT-3 of human origin by WB, IP, IF and ELISA
- Anti-NT-3 Antibody (A-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for NT-3 Antibody (A-4) for WB applications. These reagents are now offered in bundles with NT-3 Antibody (A-4) (see ordering information below).
NT-3 Antibody (A-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects neurotrophin-3 (NT-3) of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NT-3 (A-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NT-3 monoclonal antibody (A-4) recognizes a protein crucial for nervous system development and maintenance by promoting specific neuronal populations′ survival and differentiation. NT-3 is primarily located in the extracellular space, where binding to high-affinity receptor TrkC mediates neuroprotective effects. NT-3 and TrkC interaction supports sensory and motor neuron function by influencing neuronal survival and synaptic connection formation. NT-3 also interacts with other neurotrophins and receptors, contributing to a signaling network regulating neuronal health and plasticity. Research on NT-3 and receptor interactions helps develop therapeutic strategies for neurodegenerative diseases and injuries.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NT-3 Antibody (A-4) References:
- Physiological and morphological plasticity induced by chronic treatment with NT-3 or NT-4/5 in hippocampal slice cultures. | Schwyzer, L., et al. 2002. Eur J Neurosci. 16: 1939-48. PMID: 12453058
- Neurotrophin receptors: a window into neuronal differentiation. | Chao, MV. 1992. Neuron. 9: 583-93. PMID: 1327010
- The changing scene of neurotrophic factors. | Thoenen, H. 1991. Trends Neurosci. 14: 165-70. PMID: 1713715
- Cell death during development of the nervous system. | Oppenheim, RW. 1991. Annu Rev Neurosci. 14: 453-501. PMID: 2031577
- Early Postnatal NT-3 Gene Delivery Enhances Hearing Acquisition in the Developmental Period. | Jin, Y., et al. 2016. Laryngoscope. 126: E379-E385. PMID: 27328420
- Neurotrophin-3 (NT-3) as a Potential Biomarker of the Peripheral Nervous System Damage Following Breast Cancer Treatment. | Tonyan, S., et al. 2023. Pathophysiology. 30: 110-122. PMID: 37092524
- Detection and Quantification of Neurotrophin-3 (NT-3) and Nerve Growth Factor (NGF) Levels in Early Second Trimester Amniotic Fluid: Investigation into a Possible Correlation with Abnormal Fetal Growth Velocity Patterns. | Machairiotis, N., et al. 2023. J Clin Med. 12: PMID: 37373824
- Overexpression of NT-3 in the hippocampus suppresses the early phase of the adult neurogenic process. | Kasakura, N., et al. 2023. Front Neurosci. 17: 1178555. PMID: 37575306
- Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. | Ip, NY., et al. 1993. Neuron. 10: 137-49. PMID: 7679912
- Role of neurotrophins in mouse neuronal development. | Klein, R. 1994. FASEB J. 8: 738-44. PMID: 8050673
- The conservation of neurotrophic factors during vertebrate evolution. | Götz, R. and Schartl, M. 1994. Comp Biochem Physiol Pharmacol Toxicol Endocrinol. 108: 1-10. PMID: 8061955
- The neurotrophic factor concept: a reexamination. | Korsching, S. 1993. J Neurosci. 13: 2739-48. PMID: 8331370
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NT-3 Antibody (A-4) | sc-518099 | 200 µg/ml | $322.00 | |||
NT-3 Antibody (A-4): m-IgG Fc BP-HRP Bundle | sc-528089 | 200 µg Ab; 10 µg BP | $361.00 | |||
NT-3 Antibody (A-4): m-IgG1 BP-HRP Bundle | sc-533462 | 200 µg Ab; 20 µg BP | $361.00 | |||
NT-3 Antibody (A-4) AC | sc-518099 AC | 500 µg/ml, 25% agarose | $424.00 | |||
NT-3 Antibody (A-4) HRP | sc-518099 HRP | 200 µg/ml | $322.00 | |||
NT-3 Antibody (A-4) FITC | sc-518099 FITC | 200 µg/ml | $336.00 | |||
NT-3 Antibody (A-4) PE | sc-518099 PE | 200 µg/ml | $349.00 | |||
NT-3 Antibody (A-4) Alexa Fluor® 488 | sc-518099 AF488 | 200 µg/ml | $364.00 | |||
NT-3 Antibody (A-4) Alexa Fluor® 546 | sc-518099 AF546 | 200 µg/ml | $364.00 | |||
NT-3 Antibody (A-4) Alexa Fluor® 594 | sc-518099 AF594 | 200 µg/ml | $364.00 | |||
NT-3 Antibody (A-4) Alexa Fluor® 647 | sc-518099 AF647 | 200 µg/ml | $364.00 | |||
NT-3 Antibody (A-4) Alexa Fluor® 680 | sc-518099 AF680 | 200 µg/ml | $364.00 | |||
NT-3 Antibody (A-4) Alexa Fluor® 790 | sc-518099 AF790 | 200 µg/ml | $364.00 |