Molecular structure of NS 2028, CAS Number: 204326-43-2
NS 2028 (CAS 204326-43-2)
See product citations (1)
Alternate Names:
8-Bromo-4H-[1,2,4]oxadiazolo[3,4-c][1,4]benzoxazin-1-one
Application:
NS 2028 is a potent, specific, and irreversible inhibitor of soluble guanylyl cyclase
CAS Number:
204326-43-2
Purity:
≥98%
Molecular Weight:
269.05
Molecular Formula:
C9H5BrN2O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase (IC50 = 30 nM for basal and 200 nM for NO-stimulated enzyme activity; IC50 = 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum).
NS 2028 (CAS 204326-43-2) References
- Vascular smooth muscle contraction is an independent regulator of endothelial nitric oxide production. | Bang, L., et al. 1999. Scand Cardiovasc J. 33: 33-78. PMID: 10225308
- H(2)S-induced vasorelaxation and underlying cellular and molecular mechanisms. | Zhao, W. and Wang, R. 2002. Am J Physiol Heart Circ Physiol. 283: H474-80. PMID: 12124191
- The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. | Morbidelli, L., et al. 2010. Am J Physiol Regul Integr Comp Physiol. 298: R824-32. PMID: 20032260
- Formation, signaling functions, and metabolisms of nitrated cyclic nucleotide. | Sawa, T., et al. 2013. Nitric Oxide. 34: 10-8. PMID: 23632125
- The role of cGMP in ocular growth and the development of form-deprivation myopia in guinea pigs. | Fang, F., et al. 2013. Invest Ophthalmol Vis Sci. 54: 7887-902. PMID: 24130184
- Formic acid up-regulates vascular tension through nitric oxide-cGMP signaling pathway. | Zhang, Q., et al. 2019. Chem Biol Interact. 309: 108710. PMID: 31199930
- L-Arginine enhanced perylenequinone production in the endophytic fungus Shiraia sp. Slf14(w) via NO signaling pathway. | Chen, Y., et al. 2022. Appl Microbiol Biotechnol. 106: 2619-2636. PMID: 35291023
- Nitric oxide mediates red light-induced perylenequinone production in Shiraia mycelium culture. | Wang, WJ., et al. 2024. Bioresour Bioprocess. 11: 2. PMID: 38647587
- Characterization of NS 2028 as a specific inhibitor of soluble guanylyl cyclase. | Olesen, SP., et al. 1998. Br J Pharmacol. 123: 299-309. PMID: 9489619
- Isometric contraction induces the Ca2+-independent activation of the endothelial nitric oxide synthase. | Fleming, I., et al. 1999. Proc Natl Acad Sci U S A. 96: 1123-8. PMID: 9927704
Inhibitor of:
Guanylate Cyclases.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NS 2028, 5 mg | sc-202743 | 5 mg | $149.00 |