Nrf2 Antibody (H-10): sc-518036

Nrf2 Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects amino acids 37-336 of Nrf2 of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Nrf2 monoclonal antibody (H-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Nrf2, a member of the Cap ′n′ collar (CNC) family of transcription factors, plays a crucial role in cellular defense against oxidative stress by regulating the expression of detoxification enzymes and antioxidant proteins. Nrf2 is primarily located in the cytoplasm under normal conditions, where Keap1 acts as a repressor protein. Upon exposure to oxidative stress or xenobiotics, Nrf2 translocates to the nucleus, where binding to antioxidant response elements (ARE) in the promoter regions of target genes leads to the activation of protective responses. This translocation is vital for maintaining cellular homeostasis and protecting against damage caused by reactive oxygen species, making Nrf2 a key player in the cellular response to oxidative stress and a potential therapeutic target for diseases related to oxidative damage. Anti-Nrf2 antibody (H-10) serves as a powerful tool for investigating the localization, regulation, and functional significance of Nrf2 in oxidative stress pathways and cellular defense mechanisms.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Nrf2 Antibody (H-10) has 8 citations in a variety of scientific publications.

Primary antibodies like Anti-Nrf2 Antibody (H-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Nrf2 Antibody (H-10) Specifications

Alternate Product Name: Nrf2

Product Clone Name: H-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 37-336

Epitope Target: Nrf2

Epitope Species: human

Product Reactivity/Detection: Nrf2

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 8 citations in various scientific publications

Available Conjugates/Forms for Nrf2 Antibody (H-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent

The preferred Nrf2 antibody is Nrf2 Antibody (H-6): sc-518033.