Nrf1 Antibody (G-5): sc-515360

Nrf1 Antibody (G-5) is a mouse monoclonal IgG2b antibody that detects Nrf1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Nrf1 monoclonal antibody (G-5) is specific for an epitope mapping between amino acids 747-772 at the C-terminus of Nrf1 of human origin. Anti-Nrf1 antibody (G-5) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Nrf1, also known as TCF11, plays a crucial role in cellular defense mechanisms by regulating the expression of detoxification enzymes and antioxidant proteins, thereby contributing to the cellular response to oxidative stress. Nrf1 belongs to the Cap ′n′ collar (CNC) family of transcription factors, which includes Nrf2 and Nrf3, and is characterized by a basic leucine zipper (bZIP) domain that facilitates dimerization with Maf proteins to bind to specific DNA sequences known as Maf recognition elements (MAREs) and antioxidant response elements (AREs). Nrf1 can heterodimerize with Jun family members, such as c-Jun, JunB, and JunD, enhancing activation of gene expression, particularly for the detoxifying enzyme NAD(P)H:quinone oxidoreductase 1 (NQO1). Understanding Nrf1 function is vital, as this protein not only regulates genes involved in detoxification but also plays a significant role in maintaining cellular homeostasis and protecting against oxidative damage, which is linked to various diseases, including cancer and neurodegenerative disorders.

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Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Nrf1 Antibody (G-5) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Nrf1 Antibody (G-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Nrf1 Antibody (G-5) Specifications

Alternate Product Name: NFE2L1

Product Clone Name: G-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids: 747-772

Epitope Target: Nrf1

Epitope Species: human

Product Reactivity/Detection: Nrf1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Nrf1 Antibody (G-5): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin, X: TransCruz Reagent