Nrf1 Antibody (E-4): sc-365651
- Nrf1 Antibody (E-4) is a mouse monoclonal IgG3 κ, cited in 5 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 121-157 near the N-terminus of Nrf1 of human origin
- recommended for detection of Nrf1 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and canine and bovine
- m-IgG3 BP-HRP is the preferred secondary detection reagent for Nrf1 Antibody (E-4) for WB and IHC(P) applications. This reagent is now offered in a bundle with Nrf1 Antibody (E-4) (see ordering information below).
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Nrf1 Antibody (E-4) is a mouse monoclonal IgG3 antibody that detects Nrf1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Nrf1 monoclonal antibody (E-4) is specific for an epitope mapping between amino acids 121-157 near the N-terminus of Nrf1 of human origin. Anti-Nrf1 antibody (E-4), a member of the Cap ′n′ collar (CNC) family of bZIP transcription factors, plays a crucial role in cellular defense mechanisms by regulating the expression of genes involved in the antioxidant response and detoxification processes. Nrf1 is primarily located in the nucleus, where translocation occurs in response to oxidative stress and xenobiotic exposure, allowing activation of target genes such as those encoding detoxifying enzymes. Nrf1′s ability to heterodimerize with other proteins, including MafK and members of the Jun family, enhances transcriptional activity, making Nrf1 essential for maintaining cellular homeostasis and protecting against oxidative damage. Anti-Nrf1 antibody (E-4) serves as an invaluable tool for researchers studying the intricate mechanisms of oxidative stress response and the regulation of detoxification pathways in various biological contexts.
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Nrf1 Antibody (E-4) References:
- Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes. | Wang, S., et al. 2020. Int J Mol Sci. 21: PMID: 32188015
- ER-Resident Transcription Factor Nrf1 Regulates Proteasome Expression and Beyond. | Hamazaki, J. and Murata, S. 2020. Int J Mol Sci. 21: PMID: 32456207
- Mitophagy receptor FUNDC1 is regulated by PGC-1α/NRF1 to fine tune mitochondrial homeostasis. | Liu, L., et al. 2021. EMBO Rep. 22: e50629. PMID: 33554448
- NRF1-mediated microglial activation triggers high-altitude cerebral edema. | Wang, X., et al. 2022. J Mol Cell Biol. 14: PMID: 35704676
- Regulation and Functions of the ER-Associated Nrf1 Transcription Factor. | Ruvkun, G. and Lehrbach, N. 2023. Cold Spring Harb Perspect Biol. 15: PMID: 35940907
- UBE4A catalyzes NRF1 ubiquitination and facilitates DDI2-mediated NRF1 cleavage. | Hu, X., et al. 2023. Biochim Biophys Acta Gene Regul Mech. 1866: 194937. PMID: 37084817
- NRF1-mediated mitochondrial biogenesis antagonizes innate antiviral immunity. | Zhao, T., et al. 2023. EMBO J. 42: e113258. PMID: 37409632
- The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis. | Hatanaka, A., et al. 2023. Sci Rep. 13: 14405. PMID: 37658135
- ER-trafficking triggers NRF1 ubiquitination to promote its proteolytic activation. | Chavarria, C., et al. 2023. iScience. 26: 107777. PMID: 37720101
- NRF1 Alleviated Oxidative Stress of Glioblastoma Cells by Regulating NOR1. | Wang, J., et al. 2023. Folia Biol (Praha). 69: 13-21. PMID: 37962027
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Nrf1 Antibody (E-4) | sc-365651 | 200 µg/ml | $322.00 | |||
Nrf1 Antibody (E-4): m-IgG3 BP-HRP Bundle | sc-550434 | 200 µg Ab; 40 µg BP | $361.00 | |||
Nrf1 (E-4) Neutralizing Peptide | sc-365651 P | 100 µg/0.5 ml | $69.00 |