NRBP Antibody (X-13): sc-101288

NRBP Antibody (X-13) is a mouse monoclonal IgG2a antibody that detects nuclear receptor binding protein (NRBP) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NRBP is a crucial cytoplasmic protein that plays a significant role in cellular signaling and trafficking, particularly influencing the movement of proteins between the endoplasmic reticulum and the Golgi apparatus through interactions with GTPases. NRBP functions as a multidomain putative adaptor, modulating various signaling pathways by facilitating the assembly of signaling complexes in the cytoplasm. Notably, NRBP can form homodimers and interacts with MLF1, leading to the recruitment of a serine kinase that phosphorylates both proteins, thereby inhibiting MLF1′s ability to bind to YWHAZ. While NRBP is primarily located in the cytoplasm, NRBP can also co-localize with RAC3 at the endomembrane and is observed at the cell periphery in lamellipodia, highlighting a dynamic role in cellular architecture and signaling. The NRBP gene is located on human chromosome 2p23 and is expressed across various human tissues, with highest expression levels found in the testis, underscoring NRBP′s importance in both normal physiology and potential pathological conditions. Anti-NRBP antibody (X-13) is an essential tool for researchers investigating the intricate roles of NRBP in cellular processes and signaling pathways.

The preferred NRBP antibody is NRBP Antibody (C-1): sc-390087.