NQO2 Antibody (AT1E3): sc-517416
- NQO2 Antibody (AT1E3) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against a recombinant protein corresponding to amino acids 1-231 of NQO2 of human origin
- recommended for detection of NQO2 of mouse, rat and human origin by WB, IF and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NQO2 Antibody (AT1E3). This work is in progress.
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NQO2 Antibody (AT1E3) is a mouse monoclonal IgG1 antibody that detects NQO2 in mouse, rat, and human samples through applications such as western blotting (WB), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NQO2, a 231 amino acid flavoprotein, plays a crucial role in the metabolic detoxification of quinones and their derivatives, converting them into less harmful hydroquinones, thereby protecting cells from oxidative stress, cytotoxicity, and mutagenicity. NQO2 employs dihydronicotinamide riboside (NRH) as an electron donor, unlike its isozyme NQO1 which utilizes NAD(P)H, making NQO2 resistant to common inhibitors of NQO1 while being susceptible to compounds like quercetin and benzo(a)pyrene. NQO2 is widely expressed across various tissues, with notably higher levels in the liver and testis compared to NQO1, which is predominantly found in the heart. NQO2 features a specific metal binding site that is absent in NQO1, along with several regulatory elements in its promoter region, such as SP1 binding sites and the CCAAT box, which are essential for expression regulation in response to environmental stressors like TCDD. Anti-NQO2 antibody (AT1E3) serves as an invaluable tool for researchers studying protective mechanisms against oxidative damage and the intricate roles of flavoproteins in cellular metabolism.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NQO2 Antibody (AT1E3) | sc-517416 | 100 µg/ml | $322.00 |