NPT1 Antibody (4B4D1): sc-517230
- NPT1 Antibody (4B4D1) is a mouse monoclonal IgG2a NPT1 antibody provided at 50 µg/0.5 ml
- raised against toxin binding protein fragment of NPT1 of human origin
- recommended for detection of NPT1 of human origin by WB and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NPT1 Antibody (4B4D1). This work is in progress.
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NPT1 Antibody (4B4D1) is a mouse monoclonal IgG2a antibody that detects NPT1 protein of human origin by western blotting (WB) and enzyme-linked immunosorbent assay (ELISA). NPT1 (4B4D1) antibody is available as a non-conjugated anti-NPT1 monoclonal isotype antibody. NPT1 protein, also known as sodium-dependent phosphate transport protein, is a crucial member of the organic anion transporter family, specifically the SLC17A subfamily. NPT1 is predominantly expressed in the kidney, where NPT1 plays a vital role in the transport of small organic anions, such as para-aminohippurate (PAH), and is also found in the liver and brain. NPT1 is localized to the apical membrane of renal proximal tubular cells, functioning as a voltage-driven organic anion/chloride exchanger, which is essential for maintaining phosphate homeostasis in the body. NPT1 expression is intricately controlled by transcription factors HNF-1α and HNF-3β, highlighting NPT1′s importance in renal function and metabolic processes. NPT1 activity can be inhibited by compounds such as indomethacin and salicylate, which can have implications for drug interactions and therapeutic strategies.
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NPT1 Antibody (4B4D1) References:
- p-aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1. | Uchino, H., et al. 2000. Biochem Biophys Res Commun. 270: 254-9. PMID: 10733936
- Murine and human type I Na-phosphate cotransporter genes: structure and promoter activity. | Soumounou, Y., et al. 2001. Am J Physiol Renal Physiol. 281: F1082-91. PMID: 11704559
- Cloning, genetic mapping, and expression analysis of a mouse renal sodium-dependent phosphate cotransporter. | Chong, SS., et al. 1995. Am J Physiol. 268: F1038-45. PMID: 7611445
- Molecular cloning of the cDNA encoding a human renal sodium phosphate transport protein and its assignment to chromosome 6p21.3-p23. | Chong, SS., et al. 1993. Genomics. 18: 355-9. PMID: 8288239
- Comparative mapping of Na+-phosphate cotransporter genes, NPT1 and NPT2, in human and rabbit. | Kos, CH., et al. 1996. Cytogenet Cell Genet. 75: 22-4. PMID: 8995482
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NPT1 Antibody (4B4D1) | sc-517230 | 50 µg/0.5 ml | $316.00 |