NPAS1 Antibody (F-4): sc-376083
- NPAS1 Antibody (F-4) is a mouse monoclonal IgG1 κ NPAS1 antibody provided at 200 µg/ml
- raised against amino acids 371-590 mapping at the C-terminus of NPAS1 of human origin
- NPAS1 Antibody (F-4) is recommended for detection of NPAS1 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-NPAS1 Antibody (F-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for NPAS1 Antibody (F-4) for WB applications. These reagents are now offered in bundles with NPAS1 Antibody (F-4) (see ordering information below).
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NPAS1 Antibody (F-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects NPAS1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NPAS1 (F-4) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NPAS1, known as neuronal PAS domain protein 1, is a crucial transcription factor that plays a significant role in regulating gene expression in response to environmental stimuli, particularly in the brain. NPAS1 is composed of 590 amino acids and exhibits 86% sequence homology with mouse counterpart, Npas1. A key aspect of NPAS1′s function is requiring dimer formation with another basic helix-loop-helix (bHLH) protein to effectively bind to DNA, which is essential for modulating various biological processes. NPAS1 interacts with aryl hydrocarbon receptor nuclear translocator (ARNT), and expression is predominantly observed in brain tissue, highlighting importance in neurological functions. NPAS1 is implicated in regulatory pathways associated with schizophrenia and psychotic disorders, and may influence late central nervous system development by modulating erythropoietin expression in response to cellular oxygen levels. NPAS1 gene is located on human chromosome 19q13.32, underscoring relevance in genetic studies related to neurodevelopmental and psychiatric conditions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NPAS1 Antibody (F-4) References:
- Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors. | Erbel-Sieler, C., et al. 2004. Proc Natl Acad Sci U S A. 101: 13648-53. PMID: 15347806
- Novel function of neuronal PAS domain protein 1 in erythropoietin expression in neuronal cells. | Ohsawa, S., et al. 2005. J Neurosci Res. 79: 451-8. PMID: 15635607
- The neuronal PAS domain protein 3 transcription factor controls FGF-mediated adult hippocampal neurogenesis in mice. | Pieper, AA., et al. 2005. Proc Natl Acad Sci U S A. 102: 14052-7. PMID: 16172381
- Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system. | Zhou, YD., et al. 1997. Proc Natl Acad Sci U S A. 94: 713-8. PMID: 9012850
- Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway. | Hogenesch, JB., et al. 1997. J Biol Chem. 272: 8581-93. PMID: 9079689
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NPAS1 Antibody (F-4) | sc-376083 | 200 µg/ml | $322.00 | |||
NPAS1 Antibody (F-4): m-IgG Fc BP-HRP Bundle | sc-527509 | 200 µg Ab; 10 µg BP | $361.00 | |||
NPAS1 Antibody (F-4): m-IgG1 BP-HRP Bundle | sc-532882 | 200 µg Ab; 20 µg BP | $361.00 | |||
NPAS1 Antibody (F-4) AC | sc-376083 AC | 500 µg/ml, 25% agarose | $424.00 | |||
NPAS1 Antibody (F-4) HRP | sc-376083 HRP | 200 µg/ml | $322.00 | |||
NPAS1 Antibody (F-4) FITC | sc-376083 FITC | 200 µg/ml | $336.00 | |||
NPAS1 Antibody (F-4) PE | sc-376083 PE | 200 µg/ml | $349.00 | |||
NPAS1 Antibody (F-4) Alexa Fluor® 488 | sc-376083 AF488 | 200 µg/ml | $364.00 | |||
NPAS1 Antibody (F-4) Alexa Fluor® 546 | sc-376083 AF546 | 200 µg/ml | $364.00 | |||
NPAS1 Antibody (F-4) Alexa Fluor® 594 | sc-376083 AF594 | 200 µg/ml | $364.00 | |||
NPAS1 Antibody (F-4) Alexa Fluor® 647 | sc-376083 AF647 | 200 µg/ml | $364.00 | |||
NPAS1 Antibody (F-4) Alexa Fluor® 680 | sc-376083 AF680 | 200 µg/ml | $364.00 | |||
NPAS1 Antibody (F-4) Alexa Fluor® 790 | sc-376083 AF790 | 200 µg/ml | $364.00 |