NP1 Antibody (B-8): sc-374199

NP1 Antibody (B-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects NP1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). NP1 (B-8) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Neuronal pentraxin 1 (NP1) is a member of the long pentraxin family, which plays a crucial role in the central nervous system by mediating the uptake of synaptic materials, including presynaptic toxins like taipoxin. NP1 is primarily located in the brain and is essential for synapse formation and remodeling, highlighting its importance in neuronal communication and plasticity. The NP1 gene is situated on chromosome 17q25.1-q25.2, and NP1 forms multimeric complexes with other long pentraxins, such as NP2 and the neuronal pentraxin receptor (NPR). These interactions are vital for proper functioning of synaptic pathways, as NPR can form heteropentamers with NP1 and NP2, which are released from the cell membrane through proteolytic processes. The presence of several potential N-linked glycosylation sites in NP1 and NP2 suggests that post-translational modifications may further influence stability and interactions, making anti-NP1 antibody (B-8) an invaluable tool for studying synaptic dynamics and neurobiology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

NP1 Antibody (B-8) References:

1. Biochemical interactions of the neuronal pentraxins. Neuronal pentraxin (NP) receptor binds to taipoxin and taipoxin-associated calcium-binding protein 49 via NP1 and NP2.  |  Kirkpatrick, LL., et al. 2000. J Biol Chem. 275: 17786-92. PMID: 10748068
2. Inducible expression of the long pentraxin PTX3 in the central nervous system.  |  Polentarutti, N., et al. 2000. J Neuroimmunol. 106: 87-94. PMID: 10814786
3. Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization.  |  Hsu, YC. and Perin, MS. 1995. Genomics. 28: 220-7. PMID: 8530029
4. Mouse and human neuronal pentraxin 1 (NPTX1): conservation, genomic structure, and chromosomal localization.  |  Omeis, IA., et al. 1996. Genomics. 36: 543-5. PMID: 8884281
5. Long pentraxins: an emerging group of proteins with diverse functions.  |  Goodman, AR., et al. 1996. Cytokine Growth Factor Rev. 7: 191-202. PMID: 8899296

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NP1 Antibody (B-8) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-NP1 Antibody (B-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NP1 Antibody (B-8) Specifications

Alternate Product Name: NP1

Product Clone Name: B-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 158-235

Epitope Target: NP1

Epitope Species: human

Product Reactivity/Detection: NP1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for NP1 Antibody (B-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin