nov Antibody (F-8): sc-136966

nov Antibody (F-8) is a mouse monoclonal IgG1 antibody that detects nov in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). nov, also known as nephroblastoma overexpressed, CCN3, or NOVH, plays a crucial role in regulating cellular processes, particularly in tissues where calcium is a significant factor, such as the adrenal gland, central nervous system, bone and cartilage, heart muscle, and kidney. nov (F-8) antibody recognizes a unique protein within the CCN family that serves as a negative regulator of cell growth, contrasting with its counterparts, Cyr61 and CTGF, which promote cell proliferation. nov (F-8) monoclonal antibody targets a protein that inhibits myoblast differentiation through interaction with the Notch1 extracellular domain, highlighting nov′s importance in developmental biology and tissue homeostasis. Aberrant expression of nov has been linked to tumorigenesis, making nov (F-8) antibody a critical tool for understanding cancer biology. The gene encoding nov is located on human chromosome 8q24.12 and was initially identified due to its overexpression in virally induced nephroblastoma, underscoring nov′s relevance in both normal physiology and disease states. With diverse applications and significant biological implications, anti-nov antibody (F-8) serves as an essential tool for researchers investigating the roles of CCN proteins in health and disease.

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nov Antibody (F-8) References:

1. The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family.  |  Brigstock, DR. 1999. Endocr Rev. 20: 189-206. PMID: 10204117
2. Altered expression of novH is associated with human adrenocortical tumorigenesis.  |  Martinerie, C., et al. 2001. J Clin Endocrinol Metab. 86: 3929-40. PMID: 11502835
3. The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway.  |  Sakamoto, K., et al. 2002. J Biol Chem. 277: 29399-405. PMID: 12050162
4. The expression of novH in adrenocortical cells is down-regulated by TGFbeta 1 through c-Jun in a Smad-independent manner.  |  Lafont, J., et al. 2002. J Biol Chem. 277: 41220-9. PMID: 12149257
5. NOVH increases MMP3 expression and cell migration in glioblastoma cells via a PDGFR-alpha-dependent mechanism.  |  Laurent, M., et al. 2003. FASEB J. 17: 1919-21. PMID: 14519668
6. Differential expression of novH and CTGF in human glioma cell lines.  |  Xin, LW., et al. 1996. Clin Mol Pathol. 49: M91-7. PMID: 16696057
7. Nephroblastoma overexpressed (Nov) is a novel bone morphogenetic protein antagonist.  |  Canalis, E. 2007. Ann N Y Acad Sci. 1116: 50-8. PMID: 18083920
8. Cyr61, a member of ccn (connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed) family, predicts survival of patients with endometrial cancer of endometrioid subtype.  |  Watari, H., et al. 2009. Gynecol Oncol. 112: 229-34. PMID: 19007976
9. Recombinant expression, purification, and functional characterisation of connective tissue growth factor and nephroblastoma-overexpressed protein.  |  Bohr, W., et al. 2010. PLoS One. 5: e16000. PMID: 21209863
10. Cysteine-rich 61-connective tissue growth factor-nephroblastoma-overexpressed 5 (CCN5)/Wnt-1-induced signaling protein-2 (WISP-2) regulates microRNA-10b via hypoxia-inducible factor-1α-TWIST signaling networks in human breast cancer cells.  |  Haque, I., et al. 2011. J Biol Chem. 286: 43475-85. PMID: 22020939

The preferred nov antibody is nov Antibody (D-9): sc-136967.