NOS1 Antibody (52): sc-136006

NOS1 Antibody (52) is a mouse monoclonal IgG1 antibody specifically designed to detect neuronal nitric oxide synthase (nNOS), also known as NOS1 or ncNOS. NOS1 (52) antibody targets an epitope encompassing amino acids 144-262 of the rat NOS1 protein, ensuring reliable detection in both mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Neuronal nitric oxide synthase plays a crucial role in the production of nitric oxide (NO), a versatile signaling molecule involved in neurotransmission, synaptic plasticity, and the regulation of neuronal communication. The structure of NOS1 includes an N-terminal oxygenase domain and a C-terminal reductase domain, which are essential for enzymatic activity and require homodimerization for proper function. Post-translational modifications of NOS1, such as phosphorylation and S-nitrosylation, are vital for regulating activity, localization, and interaction with other proteins, thereby modulating NO production in response to various cellular signals. These modifications influence NOS1′s ability to participate in critical physiological processes and involvement in pathological conditions like neurodegenerative diseases and stroke. Understanding the post-translational regulation of NOS1 provides insights into precise control mechanisms within neurons, highlighting significance in maintaining cellular homeostasis and responding to environmental changes. Anti-NOS1 antibody (52) facilitates the detailed study of these modifications, enabling researchers to explore the dynamic regulation of NOS1 in different cellular contexts. NOS1 (52) monoclonal antibody supports advanced research into NO-mediated neuronal signaling and implications in both health and disease, ultimately contributing to the development of targeted therapeutic strategies.

The preferred NOS1 antibody is NOS1 Antibody (A-11): sc-5302.