Date published: 2025-10-17

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Norfluoxetine Hydrochloride (CAS 57226-68-3)

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Alternate Names:
γ-[4-(Trifluoromethyl)phenoxy]benzenepropanamine Hydrochloride; (±)-γ-[4-(Trifluoromethyl)phenoxy]benzenepropanamine Hydrochloride; Desmethylfluoxetine Hydrochloride
Application:
Norfluoxetine Hydrochloride is A metabolite of Fluoxetine, a selective serotonin reuptake inhibitor
CAS Number:
57226-68-3
Purity:
≥98%
Molecular Weight:
331.76
Molecular Formula:
C16H16F3NO•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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SELENBP1 inhibitors are a class of chemical compounds designed to specifically target and inhibit the activity of the SELENBP1 protein, which stands for selenium-binding protein 1. SELENBP1 is known to play a role in various cellular processes, including the response to oxidative stress, cellular metabolism, and the regulation of protein degradation. This protein has a high affinity for binding selenium, a trace element that is essential for the function of several important enzymes. By binding selenium, SELENBP1 is believed to be involved in the transport and storage of this element within cells, as well as in the modulation of selenium-dependent processes. Structurally, SELENBP1 inhibitors can encompass a wide variety of molecules, including small organic compounds, peptides, or larger biomolecules that are engineered to interact specifically with the selenium-binding site or other critical regions of the SELENBP1 protein. These inhibitors function by blocking the selenium-binding capacity of SELENBP1 or by altering its conformation, thereby preventing it from performing its normal biological functions. By inhibiting SELENBP1, these compounds can disrupt selenium homeostasis and interfere with the cellular processes that depend on selenium binding. The study of SELENBP1 inhibitors is crucial for understanding the role of selenium-binding proteins in cellular physiology and the broader implications of selenium metabolism. Research into these inhibitors provides valuable insights into the regulatory networks that govern selenium utilization and highlights the importance of selenium-binding proteins in maintaining cellular health. By exploring the effects of SELENBP1 inhibition, scientists can gain a deeper understanding of the physiological and biochemical pathways influenced by selenium, revealing the significance of these proteins in various aspects of cellular function and metabolic regulation.


Norfluoxetine Hydrochloride (CAS 57226-68-3) References

  1. Effects of norfluoxetine, the major metabolite of fluoxetine, on the cloned neuronal potassium channel Kv3.1.  |  Choi, BH., et al. 2001. Neuropharmacology. 41: 443-53. PMID: 11543764
  2. Norfluoxetine and fluoxetine have similar anticonvulsant and Ca2+ channel blocking potencies.  |  Kecskeméti, V., et al. 2005. Brain Res Bull. 67: 126-32. PMID: 16140171
  3. Fluoxetine and norfluoxetine stereospecifically and selectively increase brain neurosteroid content at doses that are inactive on 5-HT reuptake.  |  Pinna, G., et al. 2006. Psychopharmacology (Berl). 186: 362-72. PMID: 16432684
  4. Role of norfluoxetine in the inhibition of desipramine metabolism and in the inhibition of serotonin uptake after fluoxetine administration to rats.  |  Fuller, RW. and Snoddy, HD. 1991. Res Commun Chem Pathol Pharmacol. 73: 31-40. PMID: 1715593
  5. Norfluoxetine induces spawning and parturition in estuarine and freshwater bivalves.  |  Fong, PP. and Molnar, N. 2008. Bull Environ Contam Toxicol. 81: 535-8. PMID: 18787749
  6. Development of a stir bar sorptive extraction based HPLC-FLD method for the quantification of serotonin reuptake inhibitors in plasma, urine and brain tissue samples.  |  Unceta, N., et al. 2010. J Pharm Biomed Anal. 51: 178-85. PMID: 19660886
  7. In vitro modulation of estrogen receptor activity by norfluoxetine.  |  Lupu, D., et al. 2015. Clujul Med. 88: 386-90. PMID: 26609274
  8. Norfluoxetine Prevents Degeneration of Dopamine Neurons by Inhibiting Microglia-Derived Oxidative Stress in an MPTP Mouse Model of Parkinson's Disease.  |  Kim, KI., et al. 2018. Mediators Inflamm. 2018: 4591289. PMID: 30692871
  9. Detecting fluoxetine and norfluoxetine in wild bird tissues and feathers.  |  Whitlock, SE., et al. 2019. Environ Int. 126: 193-201. PMID: 30802636
  10. Norfluoxetine Is the Only Metabolite of Fluoxetine in Zebrafish (Danio rerio) Embryos That Accumulates at Environmentally Relevant Exposure Scenarios.  |  Zindler, F., et al. 2020. Environ Sci Technol. 54: 4200-4209. PMID: 32167300
  11. Norfluoxetine and venlafaxine in zebrafish larvae: Single and combined toxicity of two pharmaceutical products relevant for risk assessment.  |  Rodrigues, P., et al. 2020. J Hazard Mater. 400: 123171. PMID: 32593945
  12. Effects of norfluoxetine and venlafaxine in zebrafish larvae: Molecular data.  |  Rodrigues, P., et al. 2020. Data Brief. 33: 106515. PMID: 33294513
  13. Norfluoxetine inhibits TREK-2 K2P channels by multiple mechanisms including state-independent effects on the selectivity filter gate.  |  Proks, P., et al. 2021. J Gen Physiol. 153: PMID: 34032848
  14. Factors associated with fluoxetine and norfluoxetine plasma concentrations and clinical response in Mexican patients with mental disorders.  |  Sagahón-Azúa, J., et al. 2021. Pharmacol Res Perspect. 9: e00864. PMID: 34523245
  15. Norfluoxetine enantiomers as inhibitors of serotonin uptake in rat brain.  |  Wong, DT., et al. 1993. Neuropsychopharmacology. 8: 337-44. PMID: 8512621

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Norfluoxetine Hydrochloride, 10 mg

sc-208105
10 mg
$332.00

Norfluoxetine Hydrochloride, 100 mg

sc-208105A
100 mg
$2062.00

Norfluoxetine Hydrochloride, 500 mg

sc-208105B
500 mg
$9533.00