NOK Antibody (2H2F10): sc-81701
- NOK Antibody (2H2F10) is a mouse monoclonal IgG1 NOK antibody, cited in 1 publications, provided at 200 µg/ml
- raised against a recombinant protein corresponding to amino acids 50-225 of NOK of human origin
- NOK Antibody (2H2F10) is recommended for detection of NOK of human origin by WB, IP, IF and IHC(P)
- Anti-NOK Antibody (2H2F10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NOK Antibody (2H2F10). This work is in progress.
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SEE ALSO...
NOK Antibody (2H2F10) is a mouse monoclonal IgG1 antibody that detects NOK protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. NOK (2H2F10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NOK protein, also known as STYK1 (serine/threonine/tyrosine kinase 1), is a single-pass membrane protein consisting of 422 amino acids and is a member of the protein kinase superfamily. NOK plays a crucial role in cellular signaling pathways, particularly in the regulation of cell proliferation, differentiation, and survival, making NOK significant in cancer biology. NOK is highly expressed in the brain, prostate, and placenta, while exhibiting lower expression levels in non-cancerous lung tissue. NOK overexpression in various cancers, including ovarian cancer, cervical cancer, and chronic myelogenous leukemia, underscores NOK′s potential as a biomarker and therapeutic target in oncology. A protein kinase domain within NOK allows participation in critical phosphorylation events, which are vital for modulating a wide array of cellular functions, including those related to tumorigenesis.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NOK Antibody (2H2F10) References:
- Isolation and characterization of a human putative receptor protein kinase cDNA STYK1. | Ye, X., et al. 2003. Mol Biol Rep. 30: 91-6. PMID: 12841579
- A novel protein tyrosine kinase NOK that shares homology with platelet- derived growth factor/fibroblast growth factor receptors induces tumorigenesis and metastasis in nude mice. | Liu, L., et al. 2004. Cancer Res. 64: 3491-9. PMID: 15150103
- Diagnostic relevance of overexpressed NOK mRNA in breast cancer. | Moriai, R., et al. 2006. Anticancer Res. 26: 4969-73. PMID: 17214372
- Diagnostic relevance of overexpressed mRNA of novel oncogene with kinase-domain (NOK) in lung cancers. | Amachika, T., et al. 2007. Lung Cancer. 56: 337-40. PMID: 17298854
- Patterns of somatic mutation in human cancer genomes. | Greenman, C., et al. 2007. Nature. 446: 153-8. PMID: 17344846
- A novel gene STYK1/NOK is upregulated in estrogen receptor-alpha negative estrogen receptor-beta positive breast cancer cells following estrogen treatment. | Kimbro, KS., et al. 2008. Mol Biol Rep. 35: 23-7. PMID: 17415682
- [Preparation of anti-hNOK antibodies and expression examination of NOK in the lung cancer tissues]. | Xu, F., et al. 2008. Sheng Wu Gong Cheng Xue Bao. 24: 480-4. PMID: 18589826
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NOK Antibody (2H2F10) | sc-81701 | 200 µg/ml | $316.00 | |||
NOK Antibody (2H2F10) AC | sc-81701 AC | 500 µg/ml, 25% agarose | $416.00 | |||
NOK Antibody (2H2F10) HRP | sc-81701 HRP | 200 µg/ml | $316.00 | |||
NOK Antibody (2H2F10) FITC | sc-81701 FITC | 200 µg/ml | $330.00 | |||
NOK Antibody (2H2F10) PE | sc-81701 PE | 200 µg/ml | $343.00 | |||
NOK Antibody (2H2F10) Alexa Fluor® 488 | sc-81701 AF488 | 200 µg/ml | $357.00 | |||
NOK Antibody (2H2F10) Alexa Fluor® 546 | sc-81701 AF546 | 200 µg/ml | $357.00 | |||
NOK Antibody (2H2F10) Alexa Fluor® 594 | sc-81701 AF594 | 200 µg/ml | $357.00 | |||
NOK Antibody (2H2F10) Alexa Fluor® 647 | sc-81701 AF647 | 200 µg/ml | $357.00 | |||
NOK Antibody (2H2F10) Alexa Fluor® 680 | sc-81701 AF680 | 200 µg/ml | $357.00 | |||
NOK Antibody (2H2F10) Alexa Fluor® 790 | sc-81701 AF790 | 200 µg/ml | $357.00 |