Nogo Antibody (C-4): sc-271878

Nogo Antibody (C-4) is a mouse monoclonal IgM antibody that detects Nogo protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-Nogo antibody (C-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Nogo protein, also known as neurite outgrowth inhibitor or neuroendocrine secretion regulating protein, plays a critical role in the central nervous system by inhibiting axonal growth, which is essential for maintaining the integrity of CNS white matter. Nogo is primarily expressed by oligodendrocytes and is associated with the endoplasmic reticulum, where Nogo exists in three splice variants: Nogo-A, Nogo-B, and Nogo-C. Nogo presence in the CNS is crucial as Nogo prevents excessive axonal regeneration, which could lead to aberrant neural connections and potential dysfunction. Understanding Nogo interactions with other proteins, such as the NgR (Nogo receptor), is vital for elucidating Nogo′s role in neuroregeneration and the development of therapeutic strategies for spinal cord injuries and neurodegenerative diseases.

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LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Nogo Antibody (C-4) References:

1. Identification of the Nogo inhibitor of axon regeneration as a Reticulon protein.  |  GrandPré, T., et al. 2000. Nature. 403: 439-44. PMID: 10667797
2. Function of Nogo-A/Nogo-A receptor in Alzheimer's disease.  |  Xu, YQ., et al. 2015. CNS Neurosci Ther. 21: 479-85. PMID: 25732725
3. Nogo-A Antibodies for Progressive Multiple Sclerosis.  |  Ineichen, BV., et al. 2017. CNS Drugs. 31: 187-198. PMID: 28105588
4. RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development.  |  Wang, J., et al. 2021. Cell. 184: 5869-5885.e25. PMID: 34758294
5. RTN4/NoGo-receptor binding to BAI adhesion-GPCRs regulates neuronal development.  |  Wang, J., et al. 2022. Cell. 185: 218. PMID: 34995515

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Nogo Antibody (C-4) has 27 citations in a variety of scientific publications.

Primary antibodies like Anti-Nogo Antibody (C-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Nogo Antibody (C-4) Specifications

Alternate Product Name: Reticulon 4 (RTN4)

Product Clone Name: C-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 18-41

Epitope Target: Nogo

Epitope Species: human

Product Reactivity/Detection: Nogo A, Nogo B and foocen

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 27 citations in various scientific publications

Available Conjugates/Forms for Nogo Antibody (C-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF647: Alexa Fluor^® 647, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin