Noggin Antibody (1D2-G8-G1): sc-517561

Noggin Antibody (1D2-G8-G1) is a mouse monoclonal IgG antibody that detects Noggin in human samples by western blotting (WB). Noggin is a crucial secreted protein that plays a significant role in regulating bone morphogenetic proteins (BMPs), which are vital for various developmental processes, including skeletogenesis and neural tube patterning. By binding to and inactivating members of the transforming growth factor-beta (TGFβ) superfamily, such as BMP2, BMP4, and BMP7, Noggin (1D2-G8-G1) antibody effectively modulates BMP signaling pathways, ensuring proper embryonic development. The ability of Noggin to diffuse through extracellular matrices allows for creating morphogenetic gradients, which are essential for spatially regulating BMP activity during vertebrate development. Notably, the absence of Noggin in homozygous null mice leads to severe developmental defects, including stubby limbs and a lack of joints, underscoring Noggin′s critical function in skeletal formation and overall embryonic integrity. With specificity for human Noggin, anti-Noggin antibody (1D2-G8-G1) is an invaluable tool for researchers investigating the intricate signaling mechanisms that govern vertebrate development and the potential implications of BMP signaling dysregulation in various diseases.

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Noggin Antibody (1D2-G8-G1) References:

1. Noggin and noggin-like genes control dorsoventral axis regeneration in planarians.  |  Molina, MD., et al. 2011. Curr Biol. 21: 300-5. PMID: 21295481
2. Persistent Noggin arrests cardiomyocyte morphogenesis and results in early in utero lethality.  |  Simmons, O., et al. 2015. Dev Dyn. 244: 457-67. PMID: 25428115
3. Molecular docking based screening of Noggin inhibitors.  |  Gudipati, S., et al. 2018. Bioinformation. 14: 15-20. PMID: 29497255
4. Exogenous noggin binds the BMP-2 receptor and induces alkaline phosphatase activity in osteoblasts.  |  Hashimi, SM. 2019. J Cell Biochem. 120: 13237-13242. PMID: 30887565
5. Noggin regulates foregut progenitor cell programming, and misexpression leads to esophageal atresia.  |  Pinzon-Guzman, C., et al. 2020. J Clin Invest. 130: 4396-4410. PMID: 32427591
6. Prognostic value of noggin protein expression in patients with resected gastric cancer.  |  Chun, SH., et al. 2021. BMC Cancer. 21: 558. PMID: 34001012
7. Chemical Replacement of Noggin with Dorsomorphin Homolog 1 for Cost-Effective Direct Neuronal Conversion.  |  Böhnke, L., et al. 2022. Cell Reprogram. 24: 304-313. PMID: 35877103
8. Enhanced Osteogenic Potential of Noggin Knockout C2C12 Cells on BMP-2 Releasing Silk Scaffolds.  |  Çakmak, AS., et al. 2023. ACS Biomater Sci Eng. 9: 6175-6185. PMID: 37796024
9. Noggin promotes osteogenesis in human adipose-derived mesenchymal stem cells via FGFR2/Src/Akt and ERK signaling pathway.  |  Truchan, K. and Osyczka, AM. 2024. Sci Rep. 14: 6724. PMID: 38509118
10. Noggin-Loaded PLA/PCL Patch Inhibits BMP-Initiated Reactive Astrogliosis.  |  Hawes, J., et al. 2024. Int J Mol Sci. 25: PMID: 39519177

The preferred Noggin antibody is Noggin Antibody (2C10): sc-293439.