Noggin Antibody (2C10): sc-293439

Noggin Antibody (2C10) is a mouse monoclonal IgG2b kappa light chain antibody that detects Noggin protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Noggin antibody (2C10) is available as the non-conjugated format. Noggin protein plays a crucial role in embryonic development by regulating the activity of bone morphogenetic proteins (BMPs), which are essential for the formation of bones and cartilage. Specifically, Noggin binds to and inhibits BMPs, preventing them from triggering their signaling pathways, which is vital for proper skeletal development and neural tube patterning. The ability of Noggin to diffuse through extracellular matrices allows Noggin to create morphogenetic gradients necessary for spatial regulation of BMP activity during development. In mice embryos homozygous null for Noggin, severe developmental defects occur, including stubby limbs without joints and various malformations, highlighting Noggin′s importance in vertebrate skeletogenesis.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Noggin Antibody (2C10) References:

1. Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis.  |  Gong, Y., et al. 1999. Nat Genet. 21: 302-4. PMID: 10080184
2. NOGGIN: a new therapeutic target for PH? Focus on 'Noggin inhibits hypoxia-induced proliferation by targeting store-operated calcium entry and transient receptor potential cation channels'.  |  Boucherat, O. and Bonnet, S. 2015. Am J Physiol Cell Physiol. 308: C867-8. PMID: 25832472
3. Differential compartmentalization of BMP4/NOGGIN requires NOGGIN trans-epithelial transport.  |  Phan-Everson, T., et al. 2021. Dev Cell. 56: 1930-1944.e5. PMID: 34051144
4. Noggin proteins are multifunctional extracellular regulators of cell signaling.  |  Karunaraj, P., et al. 2022. Genetics. 221: PMID: 35357435
5. Neuroprotective role of Noggin in spinal cord injury.  |  Al-Sammarraie, N., et al. 2023. Neural Regen Res. 18: 492-496. PMID: 36018152
6. BMP-2 and Noggin Immunoexpression in Ameloblastomas, Odontogenic Keratocysts, and Dentigerous Cysts.  |  Andrade Santos, PP., et al. 2023. Appl Immunohistochem Mol Morphol. 31: 40-46. PMID: 36315234
7. Noggin-mediated effects on metabolite profiles of microglia and oligodendrocytes after ischemic insult.  |  Lee, J., et al. 2023. J Pharm Biomed Anal. 224: 115196. PMID: 36529041
8. Application of Noggin-Coated Electrospun Scaffold in Corneal Wound Healing.  |  Mahmood, N., et al. 2023. Transl Vis Sci Technol. 12: 15. PMID: 37594449
9. Noggin contributes to brain metastatic colonization of lung cancer cells.  |  Lee, JE., et al. 2023. Cancer Cell Int. 23: 299. PMID: 38012621
10. Identification of mammalian noggin and its expression in the adult nervous system.  |  Valenzuela, DM., et al. 1995. J Neurosci. 15: 6077-84. PMID: 7666191
11. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4.  |  Zimmerman, LB., et al. 1996. Cell. 86: 599-606. PMID: 8752214
12. Noggin-mediated antagonism of BMP signaling is required for growth and patterning of the neural tube and somite.  |  McMahon, JA., et al. 1998. Genes Dev. 12: 1438-52. PMID: 9585504

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Noggin Antibody (2C10) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-Noggin Antibody (2C10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Noggin Antibody (2C10) Specifications

Alternate Product Name: Noggin

Product Clone Name: 2C10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 27-145

Epitope Target: Noggin

Epitope Species: human

Product Reactivity/Detection: Noggin

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for Noggin Antibody (2C10): N/A