NMDAε4 Antibody (G-10): sc-17822

NMDAε4 Antibody (G-10) is a mouse monoclonal IgG2a kappa light chain antibody that detects NMDA epsilon 4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-NMDAε4 antibody (G-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. NMDA epsilon 4 protein, also known as glutamate ionotropic receptor NMDA type subunit 2D, plays a crucial role in synaptic plasticity and memory function, making this protein essential for cognitive processes. Located primarily in the postsynaptic membrane of neurons, NMDA receptors, including the epsilon 4 subunit, are activated by the binding of glutamate and glycine, allowing calcium ions to flow into the cell. This influx of calcium is vital for various intracellular signaling pathways that influence synaptic strength and neuronal survival. The unique structure of NMDA receptors, which includes a combination of different subunits, allows for diverse functional properties and regulatory mechanisms, highlighting NMDAε4′s importance in both normal brain function and in the pathophysiology of neurological disorders.

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NMDAε4 Antibody (G-10) References:

1. Fast and slow components of unitary EPSCs on stellate cells elicited by focal stimulation in slices of rat visual cortex.  |  Stern, P., et al. 1992. J Physiol. 449: 247-78. PMID: 1326045
2. Molecular diversity of glutamate receptors and implications for brain function.  |  Nakanishi, S. 1992. Science. 258: 597-603. PMID: 1329206
3. The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death.  |  Choi, DW. and Rothman, SM. 1990. Annu Rev Neurosci. 13: 171-82. PMID: 1970230
4. GluN2D expression is regulated by restraint stress and supports active stress coping bouts.  |  Doyle, MA., et al. 2023. Neuropharmacology. 225: 109377. PMID: 36528117
5. GluN2D Subunit in Parvalbumin Interneurons Regulates Prefrontal Cortex Feedforward Inhibitory Circuit and Molecular Networks Relevant to Schizophrenia.  |  Gawande, DY., et al. 2023. Biol Psychiatry. 94: 297-309. PMID: 37004850
6. GluN2D subunit-containing NMDA receptors regulate reticular thalamic neuron function and seizure susceptibility.  |  Gawande, DY., et al. 2023. Neurobiol Dis. 181: 106117. PMID: 37031803
7. Potential Roles for the GluN2D NMDA Receptor Subunit in Schizophrenia.  |  Vinnakota, C., et al. 2023. Int J Mol Sci. 24: PMID: 37511595
8. Inhibition of GluN2D-Containing NMDA Receptors Protects Dopaminergic Neurons against 6-OHDA-Induced Neurotoxicity via Activating ERK/NRF2/HO-1 Signaling.  |  Zhang, JB., et al. 2024. ACS Chem Neurosci. 15: 572-581. PMID: 38277219
9. Distinct distributions of five NMDA receptor channel subunit mRNAs in the brainstem.  |  Watanabe, M., et al. 1994. J Comp Neurol. 343: 520-31. PMID: 7518475
10. Cloned glutamate receptors.  |  Hollmann, M. and Heinemann, S. 1994. Annu Rev Neurosci. 17: 31-108. PMID: 8210177
11. A synaptic model of memory: long-term potentiation in the hippocampus.  |  Bliss, TV. and Collingridge, GL. 1993. Nature. 361: 31-9. PMID: 8421494
12. Rat GluR7 and a carboxy-terminal splice variant, GluR7b, are functional kainate receptor subunits with a low sensitivity to glutamate.  |  Schiffer, HH., et al. 1997. Neuron. 19: 1141-6. PMID: 9390526

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NMDAε4 Antibody (G-10) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-NMDAε4 Antibody (G-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NMDAε4 Antibody (G-10) Specifications

Alternate Product Name: GRIN2D

Product Clone Name: G-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 268-386

Epitope Target: NMDAε4

Epitope Species: human

Product Reactivity/Detection: NMDAε4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for NMDAε4 Antibody (G-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin