NKp46 Antibody (n1D9): sc-59343
- NKp46 Antibody (n1D9) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against full length NKp46 of human origin
- recommended for detection of NKp46 of human origin by WB, FCM and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NKp46 Antibody (n1D9). This work is in progress.
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NKp46 Antibody (n1D9) is a mouse monoclonal IgG1 antibody that detects NKp46 in human samples through applications such as western blotting (WB), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). NKp46 is a crucial natural cytotoxicity receptor belonging to the immunoglobulin superfamily, predominantly expressed on all resting and activated natural killer (NK) cells, while absent in T and B cells. NKp46 plays a vital role in the immune response by facilitating the recognition and lysis of tumor cells, as well as cells infected by viruses such as influenza and parainfluenza. NKp46 is characterized by its structure as a type I transmembrane protein, consisting of a 304 amino acid extracellular region that includes two cysteine-bridged C2-type immunoglobulin-like domains, linked to a 19 amino acid transmembrane domain rich in arginine. The unique structural features of NKp46 enable receptor engagement with target cells effectively, allowing NK cells to eliminate virus-infected and malignant cells without prior antigen stimulation. Anti-NKp46 antibody (n1D9) serves as an invaluable tool for researchers studying the mechanisms of natural cytotoxicity and the role of NK cells in immune surveillance.
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NKp46 Antibody (n1D9) References:
- NKp46 Receptor-Mediated Interferon-γ Production by Natural Killer Cells Increases Fibronectin 1 to Alter Tumor Architecture and Control Metastasis. | Glasner, A., et al. 2018. Immunity. 48: 107-119.e4. PMID: 29329948
- Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity. | Gauthier, L., et al. 2019. Cell. 177: 1701-1713.e16. PMID: 31155232
- Control of acute myeloid leukemia by a trifunctional NKp46-CD16a-NK cell engager targeting CD123. | Gauthier, L., et al. 2023. Nat Biotechnol. 41: 1296-1306. PMID: 36635380
- NKp46-specific single domain antibodies enable facile engineering of various potent NK cell engager formats. | Lipinski, B., et al. 2023. Protein Sci. 32: e4593. PMID: 36775946
- The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells. | Sen Santara, S., et al. 2023. Nature. 616: 348-356. PMID: 37020026
- Derivation and Preclinical Characterization of CYT-303, a Novel NKp46-NK Cell Engager Targeting GPC3. | Arulanandam, A., et al. 2023. Cells. 12: PMID: 37048069
- Amplification of autoimmune organ damage by NKp46-activated ILC1s. | Biniaris-Georgallis, SI., et al. 2024. Nature. 634: 952-960. PMID: 39137897
- An engineered NKp46 antibody for construction of multi-specific NK cell engagers. | Lee, RB., et al. 2024. Protein Eng Des Sel. 37: PMID: 39163262
- GPX4 restricts ferroptosis of NKp46+ILC3s to control intestinal inflammation. | Li, X., et al. 2024. Cell Death Dis. 15: 687. PMID: 39300068
- Advancements in the Study of the Immune Molecule NKp46 in Immune System-related Diseases. | Qian, S., et al. 2024. Clin Rev Allergy Immunol. 67: 96-110. PMID: 39612130
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NKp46 Antibody (n1D9) | sc-59343 | 100 µg/ml | $322.00 |