NGFR p75 Antibody (192-IgG): sc-71691

NGFR p75 Antibody (192-IgG) is a mouse monoclonal IgG1 antibody that detects NGFR p75 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). NGFR p75, also known as p75 neurotrophin receptor, plays a crucial role in the nervous system by modulating the effects of neurotrophic factors, including nerve growth factor (NGF). NGFR p75 is primarily located on the surface of neurons and is essential for neuronal survival, differentiation, and apoptosis. The interaction between NGFR p75 and neurotrophic factors is characterized by low-affinity binding, which allows for the fine-tuning of neuronal responses to these growth factors. NGFR p75 enhances the signaling efficiency of high-affinity Trk receptors, such as Trk A, by accelerating their activation and facilitating the recruitment of downstream signaling molecules. This cooperative interaction is vital for proper functioning of neuronal circuits and has implications in neurodegenerative diseases and injury responses, making NGFR p75 a key target for research in neurobiology and therapeutic interventions. Anti-NGFR p75 antibody (192-IgG) is an invaluable tool for studying these complex signaling pathways and their impact on neuronal health and disease.

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NGFR p75 Antibody (192-IgG) References:

1. Role of neurotrophin receptor p75NTR in mediating neuronal cell death following injury.  |  Coulson, EJ., et al. 2000. Clin Exp Pharmacol Physiol. 27: 537-41. PMID: 10874514
2. Osmotic swelling induces p75 neurotrophin receptor (p75NTR) expression via nitric oxide.  |  Peterson, S. and Bogenmann, E. 2003. J Biol Chem. 278: 33943-50. PMID: 12821676
3. Proteome changes induced by overexpression of the p75 neurotrophin receptor (p75NTR) in breast cancer cells.  |  Wilmet, JP., et al. 2011. Int J Dev Biol. 55: 801-9. PMID: 22161836
4. Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation.  |  Pearn, ML., et al. 2012. Anesthesiology. 116: 352-61. PMID: 22198221
5. Glucose homeostasis and p75NTR: the sweet side of neurotrophin receptor signaling.  |  Baeza-Raja, B. and Akassoglou, K. 2012. Cell Cycle. 11: 3151-2. PMID: 22894898
6. p75 neurotrophin receptor and its novel interaction partner, NIX, are involved in neuronal apoptosis after intracerebral hemorrhage.  |  Shen, J., et al. 2017. Cell Tissue Res. 368: 13-27. PMID: 27726026
7. SOST, an LNGFR target, inhibits the osteogenic differentiation of rat ectomesenchymal stem cells.  |  Li, G., et al. 2018. Cell Prolif. 51: e12412. PMID: 29226516
8. The p75 neurotrophin receptor might mediate sepsis-induced synaptic and cognitive impairments.  |  Ji, M., et al. 2018. Behav Brain Res. 347: 339-349. PMID: 29604364
9. Retrograde Degenerative Signaling Mediated by the p75 Neurotrophin Receptor Requires p150Glued Deacetylation by Axonal HDAC1.  |  Pathak, A., et al. 2018. Dev Cell. 46: 376-387.e7. PMID: 30086304
10. Identification and application of p75 neurotrophin receptor-expressing human trabecular meshwork progenitor cells.  |  Hara, S., et al. 2019. Biochem Biophys Res Commun. 514: 580-585. PMID: 31060779

The preferred NGFR p75 antibody is NGFR p75 Antibody (ME20.4): sc-13577.