NGFR p75 Antibody (192-IgG): sc-71691

NGFR p75 Antibody (192-IgG) is a mouse monoclonal IgG1 antibody that detects NGFR p75 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). NGFR p75, also known as p75 neurotrophin receptor, plays a crucial role in the nervous system by modulating the effects of neurotrophic factors, including nerve growth factor (NGF). NGFR p75 is primarily located on the surface of neurons and is essential for neuronal survival, differentiation, and apoptosis. The interaction between NGFR p75 and neurotrophic factors is characterized by low-affinity binding, which allows for the fine-tuning of neuronal responses to these growth factors. NGFR p75 enhances the signaling efficiency of high-affinity Trk receptors, such as Trk A, by accelerating their activation and facilitating the recruitment of downstream signaling molecules. This cooperative interaction is vital for proper functioning of neuronal circuits and has implications in neurodegenerative diseases and injury responses, making NGFR p75 a key target for research in neurobiology and therapeutic interventions. Anti-NGFR p75 antibody (192-IgG) is an invaluable tool for studying these complex signaling pathways and their impact on neuronal health and disease.

The preferred NGFR p75 antibody is NGFR p75 Antibody (ME20.4): sc-13577.