NGAL Antibody (ABS 039-08): sc-80561

NGAL Antibody (ABS 039-08) is a mouse monoclonal IgG1 kappa light chain antibody that detects NGAL in mouse and rat samples through immunofluorescence (IF) and enzyme-linked immunosorbent assay (ELISA) applications. Anti-NGAL antibody (ABS 039-08) is available in a non-conjugated form, allowing for versatile experimental setups. NGAL, also known as Lipocalin 2, plays a crucial role in the immune response, particularly in the context of inflammation. NGAL is primarily located in the extracellular space and is secreted by various cell types, including neutrophils and epithelial cells, during inflammatory processes. This localization is significant as NGAL interacts with and modulates the activity of other immune cells, thereby influencing the overall inflammatory response. Notably, NGAL has been shown to bind to bacterial products, which suggests a function as a scavenger that helps to mitigate inflammation and protect tissues from damage during immune challenges. NGAL is involved in the regulation of iron homeostasis and has been implicated in various pathological conditions, including cancer and kidney injury, making NGAL a valuable biomarker for disease diagnosis and prognosis.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

NGAL Antibody (ABS 039-08) References:

1. Neutrophil gelatinase-associated lipocalin as a marker of acute renal disease.  |  Haase, M., et al. 2011. Curr Opin Hematol. 18: 11-8. PMID: 21102325
2. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for early acute kidney injury.  |  Shemin, D. and Dworkin, LD. 2011. Crit Care Clin. 27: 379-89. PMID: 21440207
3. Neutrophil gelatinase-associated lipocalin regulates gut microbiota of mice.  |  Mori, K., et al. 2016. J Gastroenterol Hepatol. 31: 145-54. PMID: 26189649
4. Elevation of plasma neutrophil gelatinase-associated lipocalin (NGAL) levels in schizophrenia patients.  |  Wei, L., et al. 2018. J Affect Disord. 226: 307-312. PMID: 29028592
5. Neutrophil gelatinase-associated lipocalin in patients with sarcoidosis.  |  Kato, S., et al. 2018. Respir Med. 138S: S20-S23. PMID: 29373174
6. Neutrophil Gelatinase-Associated Lipocalin (NGAL) in predicting acute kidney injury following orthotopic liver transplantation: A systematic review.  |  Yeung, ACY., et al. 2018. Int J Surg. 59: 48-54. PMID: 30273683
7. Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) in HCV-Positive Egyptian Patients Treated with Sofosbuvir.  |  Nada, A., et al. 2020. Can J Gastroenterol Hepatol. 2020: 1632959. PMID: 32083035
8. Serum Neutrophil Gelatinase-associated Lipocalin (NGAL) Is Elevated in Patients with Asthma and Airway Obstruction.  |  Kawagoe, J., et al. 2021. Curr Med Sci. 41: 323-328. PMID: 33877549
9. Elevated plasma level of neutrophil gelatinase-associated lipocalin (NGAL) in patients with breast cancer.  |  Wei, CT., et al. 2021. Int J Med Sci. 18: 2689-2696. PMID: 34104101
10. Role of Neutrophil Gelatinase-associated Lipocalin (NGAL) and Other Clinical Parameters as Predictors of Bacterial Sepsis in Patients Presenting to the Emergency Department with Fever.  |  Paul, A., et al. 2023. Indian J Crit Care Med. 27: 176-182. PMID: 36960119

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NGAL Antibody (ABS 039-08) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-NGAL Antibody (ABS 039-08) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NGAL Antibody (ABS 039-08) Specifications

Alternate Product Name: Lipocalin 2

Product Clone Name: ABS 039-08

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids:

Epitope Target: NGAL

Epitope Species: rat

Product Reactivity/Detection: NGAL

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for NGAL Antibody (ABS 039-08): N/A

The preferred NGAL antibody is NGAL Antibody (H-4): sc-518095.