NFκB p52/p100/NFKB2 Antibody (C-5): sc-7386

NFκB p52 Antibody (C-5) is a mouse monoclonal IgG2a kappa light chain antibody that detects NFκB p52 protein of mouse, rat, and human origin through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). NFκB p52 (C-5) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase, phycoerythrin, fluorescein isothiocyanate, and multiple Alexa Fluor® conjugates. NFκB p52 plays a crucial role in the regulation of immune response, cell survival, and inflammation, making NFκB p52 an important target for understanding various diseases, including cancer and autoimmune disorders. NFκB p52 is generated through the processing of its precursor, p105, and forms heterodimers with other NFκB subunits, such as p65, to activate transcription of target genes. NFκB p52 interaction with p65 enhances the transcriptional activity of the NFκB complex, which is vital for the expression of genes involved in immune and inflammatory responses. Understanding NFκB p52 function and interactions is essential for elucidating NFκB p52 role in pathophysiological processes and developing targeted therapies.

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NFκB p52/p100/NFKB2 Antibody (C-5) References:

1. NFkappaB1/p50 is not required for tumor necrosis factor-stimulated growth of primary mammary epithelial cells: implications for NFkappaB2/p52 and RelB.  |  Zhang, J., et al. 2007. Endocrinology. 148: 268-78. PMID: 17008396
2. Fucoidan prevents C epsilon germline transcription and NFkappaB p52 translocation for IgE production in B cells.  |  Oomizu, S., et al. 2006. Biochem Biophys Res Commun. 350: 501-7. PMID: 17027924
3. RelB, a new Rel family transcription activator that can interact with p50-NF-kappa B.  |  Ryseck, RP., et al. 1992. Mol Cell Biol. 12: 674-84. PMID: 1732739
4. Cloning of an NF-kappa B subunit which stimulates HIV transcription in synergy with p65.  |  Schmid, RM., et al. 1991. Nature. 352: 733-6. PMID: 1876189
5. Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal.  |  Ghosh, S., et al. 1990. Cell. 62: 1019-29. PMID: 2203532
6. NF-kappa B, KBF1, dorsal, and related matters.  |  Gilmore, TD. 1990. Cell. 62: 841-3. PMID: 2203533
7. Cloning of a mitogen-inducible gene encoding a kappa B DNA-binding protein with homology to the rel oncogene and to cell-cycle motifs.  |  Bours, V., et al. 1990. Nature. 348: 76-80. PMID: 2234062
8. Nuclear factor κB2 p52 protein has a role in antiviral immunity through IκB kinase epsilon-dependent induction of Sp1 protein and interleukin 15.  |  Doyle, SL., et al. 2013. J Biol Chem. 288: 25066-25075. PMID: 23873932
9. A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB.  |  Baeuerle, PA. and Baltimore, D. 1989. Genes Dev. 3: 1689-98. PMID: 2691328
10. Multiple nuclear factors interact with the immunoglobulin enhancer sequences.  |  Sen, R. and Baltimore, D. 1986. Cell. 46: 705-16. PMID: 3091258
11. Inherited human RelB deficiency impairs innate and adaptive immunity to infection.  |  Le Voyer, T., et al. 2024. Proc Natl Acad Sci U S A. 121: e2321794121. PMID: 39231201
12. Highly-expressed p100/p52 (NFKB2) sequesters other NF-kappa B-related proteins in the cytoplasm of human breast cancer cells.  |  Dejardin, E., et al. 1995. Oncogene. 11: 1835-41. PMID: 7478612

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-NFκB p52/p100/NFKB2 Antibody (C-5) has 204 citations in a variety of scientific publications.

Primary antibodies like Anti-NFκB p52/p100/NFKB2 Antibody (C-5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

NFκB p52/p100/NFKB2 Antibody (C-5) Specifications

Alternate Product Name: NFKB2

Product Clone Name: C-5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 1-447

Epitope Target: NFκB p52

Epitope Species: human

Product Reactivity/Detection: NFκB p52 and p100

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 204 citations in various scientific publications

Available Conjugates/Forms for NFκB p52/p100/NFKB2 Antibody (C-5): AC: Agarose, AF405: Alexa Fluor^® 405, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent