NFATc2IP Antibody (FT-113): sc-134403
- NFATc2IP Antibody (FT-113) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against recombinant NFATc2IP protein of human origin
- recommended for detection of NFATc2IP of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NFATc2IP Antibody (FT-113). This work is in progress.
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NFATc2IP Antibody (FT-113) is a mouse monoclonal IgG1 antibody that detects NFATc2IP in human samples through applications such as western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). NFATc2IP, also known as NIP45, is a 419 amino acid protein that plays a crucial role in the immune response by localizing to both the nucleus and cytoplasm, where NFATc2IP interacts with key proteins such as NFATc2, TRAF1, and TRAF2. This interaction is vital for the inducible expression of cytokines in T-cells, particularly in enhancing interleukin production, which is essential for effective immune signaling. NFATc2IP exists in three alternatively spliced isoforms and undergoes post-translational methylation, a modification that significantly enhances NFATc2IP′s ability to regulate cytokine production. The gene encoding NFATc2IP is located on human chromosome 16, a region associated with various genetic disorders, including giant axonal neuropathy and Rubinstein-Taybi syndrome, highlighting NFATc2IP′s importance in both normal immune function and disease states. With NFATc2IP′s ability to facilitate critical immune responses, anti-NFATc2IP antibody (FT-113) serves as a significant tool for research into T-cell activation and related therapeutic strategies.
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NFATc2IP Antibody (FT-113) References:
- Novel mutations in a Japanese patient with CD19 deficiency. | Kanegane, H., et al. 2007. Genes Immun. 8: 663-70. PMID: 17882224
- Establishment of a human cell line stably overexpressing mouse Nip45 and characterization of Nip45 subcellular localization. | Hashiguchi, K., et al. 2013. Biochem Biophys Res Commun. 430: 72-7. PMID: 23159618
- [Regulatory effects of cyclosporin A and tacrolimus on the immunological gene expressions in renal transplant recipients]. | Wen, J., et al. 2012. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 34: 563-6. PMID: 23286399
- The studies of chlorogenic Acid antitumor mechanism by gene chip detection: the immune pathway gene expression. | Kang, TY., et al. 2013. J Anal Methods Chem. 2013: 617243. PMID: 23762780
- New candidate genes for ST-elevation myocardial infarction. | Cederström, S., et al. 2020. J Intern Med. 287: 66-77. PMID: 31589004
- Calcium channel TRPV6 promotes breast cancer metastasis by NFATC2IP. | Xu, X., et al. 2021. Cancer Lett. 519: 150-160. PMID: 34265397
- An Analysis of Clinical and Pathologic Features, RecurIndex Genomic Profiles, and Survival Outcomes in HER2-Low Breast Cancer. | Hui, T., et al. 2023. Oncologist. 28: e1160-e1169. PMID: 37279952
- Porcine transient receptor potential channel 1 (TRPC1) regulates muscle growth via the Wnt/β-catenin and Wnt/Ca2+ pathways. | Hao, X., et al. 2024. Int J Biol Macromol. 265: 130855. PMID: 38490377
- NFATC2IP is a mediator of SUMO-dependent genome integrity. | Cho, T., et al. 2024. Genes Dev. 38: 233-252. PMID: 38503515
- miR-31-5p suppresses myocardial hypertrophy by targeting Nfatc2ip. | Zhao, L., et al. 2024. J Cell Mol Med. 28: e18413. PMID: 38894694
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NFATc2IP Antibody (FT-113) | sc-134403 | 100 µg/ml | $339.00 |