NF-YC Antibody (C-2): sc-390861

NF-YC Antibody (C-2) is a mouse monoclonal IgG3 antibody that detects NF-YC in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NF-YC, a crucial component of the CCAAT-binding factor NF-Y, plays a significant role in gene regulation by binding to CCAAT sequences in the promoter regions of various eukaryotic genes, thereby influencing transcriptional activity. The NF-Y complex is composed of three subunits: NF-YA, NF-YB, and NF-YC, with all three being essential for effective DNA binding. NF-YC is located in the nucleus, where NF-YC participates in the assembly of the NF-Y complex, facilitating the transcription of genes involved in critical cellular processes such as cell cycle regulation and differentiation. The interaction between NF-YB and NF-YC subunits is particularly interesting, as these subunits engage in a protein-protein interaction through a histone-fold "handshake" motif, which is analogous to the interactions seen in histone proteins. This structural similarity underscores the evolutionary conservation of the NF-Y complex and highlights NF-YC′s importance in maintaining proper gene expression across different species. NF-YC (C-2) antibody is an invaluable tool for researchers studying transcriptional regulation and the molecular mechanisms underlying various biological processes.

The preferred NF-YC antibody is NF-YC Antibody (G-12): sc-390985.