NF-E2 p18 Antibody (132I2G): sc-517604
- NF-E2 p18 Antibody (132I2G) is a mouse monoclonal IgG1 κ provided at 100 µg/ml
- raised against KLH-coupled NF-E2 p18 of human origin
- recommended for detection of NF-E2 p18 of human origin by WB and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NF-E2 p18 Antibody (132I2G). This work is in progress.
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NF-E2 p18 Antibody (132I2G) is a mouse monoclonal IgG1 antibody that detects NF-E2 p18 in human samples through applications such as western blotting (WB) and flow cytometry (FCM). NF-E2 p18, also known as NF-E2U or MafK, is a crucial component of the NF-E2 transcription factor complex, which plays a significant role in regulating gene expression during erythroid differentiation. NF-E2 p18 is characterized by its basic-leucine zipper domain, which is essential for both DNA binding and dimerization, allowing NF-E2 p18 to form an obligate heterodimer with NF-E2 p45. The interaction between NF-E2 p18 and NF-E2 p45 is vital for the transcriptional regulation of globulin genes in developing erythroid cells, as NF-E2 p18 recognizes specific DNA motifs that are critical for gene activation. Additionally, NF-E2 p18 is ubiquitously expressed, indicating potential involvement in various cellular processes beyond erythropoiesis. Understanding the function and interactions of NF-E2 p18 is important for elucidating its role in hematopoiesis and implications in related disorders.
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NF-E2 p18 Antibody (132I2G) References:
- Transgenic over-expression of MafK suppresses T cell proliferation and function in vivo. | Yoh, K., et al. 2001. Genes Cells. 6: 1055-66. PMID: 11737266
- MafK/NF-E2 p18 is required for beta-globin genes activation by mediating the proximity of LCR and active beta-globin genes in MEL cell line. | Du, MJ., et al. 2008. Int J Biochem Cell Biol. 40: 1481-93. PMID: 18308612
- MafK positively regulates NF-κB activity by enhancing CBP-mediated p65 acetylation. | Hwang, YJ., et al. 2013. Sci Rep. 3: 3242. PMID: 24247732
- β-Cell-Specific Mafk Overexpression Impairs Pancreatic Endocrine Cell Development. | Abdellatif, AM., et al. 2016. PLoS One. 11: e0150010. PMID: 26901059
- The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB. | Okita, Y., et al. 2017. Sci Signal. 10: PMID: 28400538
- MafK Mediates Chromatin Remodeling to Silence IRF8 Expression in Non-immune Cells in a Cell Type-SpecificManner. | Fourier, N., et al. 2020. J Mol Biol. 432: 4544-4560. PMID: 32534063
- MAFK Polymorphisms Located in 3'-UTR are Associated with Severity of Atrophy and CDKN2A Methylation Status in the Gastric Mucosa. | Hayashi, T., et al. 2021. Genet Test Mol Biomarkers. 25: 255-262. PMID: 33877894
- MafK accelerates Salmonella mucosal infection through caspase-3 activation. | Xu, S., et al. 2022. Aging (Albany NY). 14: 2287-2303. PMID: 35260530
- NF-E2p18/mafK is required in DMSO-induced differentiation of Friend erythroleukemia cells by enhancing NF-E2 activity. | Francastel, C., et al. 1997. Leukemia. 11: 273-80. PMID: 9009092
- A core region of the mafK gene IN promoter directs neurone-specific transcription in vivo. | Motohashi, H., et al. 1998. Genes Cells. 3: 671-84. PMID: 9893024
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NF-E2 p18 Antibody (132I2G) | sc-517604 | 100 µg/ml | $322.00 |