NF-1 Antibody (F-2): sc-398751
- NF-1 Antibody (F-2) is a mouse monoclonal IgG1 provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-31 at the N-terminus of NF-1 of human origin
- recommended for detection of all NF-1 isoforms of mouse, rat and human origin by WB, IP, IF and ELISA
- TransCruz reagent for ChIP application (sc-398751 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for NF-1 Antibody (F-2). This work is in progress.
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SEE ALSO...
NF-1 Antibody (F-2) is a mouse monoclonal IgG1 antibody that detects NF-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NF-1, also known as CTF, is a crucial member of the CCAAT box binding protein family, playing a significant role in stimulating DNA replication and activating transcription. NF-1 binds to specific DNA elements as a homodimer, utilizing an amino-terminal DNA binding domain, and activates transcription through a unique proline-rich carboxy-terminal transactivation domain. NF-1 interacts with the adenovirus type 2 promoter and participates in transcriptional activation of herpes simplex virus thymidine kinase genes. The consensus element recognized by NF-1 is present in upstream promoter regions of numerous eukaryotic genes, including Ha-Ras, α-globin, HSP 70, GRP 78, Histone H1, and myelin basic protein, as well as in the Xenopus laevis vitellogenin gene promoter. The versatility of anti-NF-1 antibody (F-2) in regulating gene expression makes this antibody an essential tool for researchers studying transcriptional regulation and its implications in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
NF-1 Antibody (F-2) References:
- NF1 gene and neurofibromatosis 1. | Rasmussen, SA. and Friedman, JM. 2000. Am J Epidemiol. 151: 33-40. PMID: 10625171
- Identification of large NF1 duplications reciprocal to NAHR-mediated type-1 NF1 deletions. | Kehrer-Sawatzki, H., et al. 2014. Hum Mutat. 35: 1469-75. PMID: 25205021
- Multiple roles of NF1 in the melanocyte lineage. | Larribère, L. and Utikal, J. 2016. Pigment Cell Melanoma Res. 29: 417-25. PMID: 27155159
- Telomere erosion in NF1 tumorigenesis. | Jones, RE., et al. 2017. Oncotarget. 8: 40132-40139. PMID: 28454108
- Haploinsufficiency of the NF1 gene is associated with protection against diabetes. | Kallionpää, RA., et al. 2021. J Med Genet. 58: 378-384. PMID: 32571896
- Classification of NF1 microdeletions and its importance for establishing genotype/phenotype correlations in patients with NF1 microdeletions. | Kehrer-Sawatzki, H. and Cooper, DN. 2021. Hum Genet. 140: 1635-1649. PMID: 34535841
- Insights into the Pathogenesis of NF1-Associated Neoplasms. | Bui, A., et al. 2021. JID Innov. 1: PMID: 34604833
- Management of NF-1 dystrophic scoliosis associated with rib heads dislocation into the spinal canal in neurological intact patients: a systematic literature review. | Estefan, MM., et al. 2022. Spine Deform. 10: 285-294. PMID: 34705252
- How to select the lowest instrumented vertebra in NF-1 non-dystrophic scoliosis. | Shao, X., et al. 2023. Eur Spine J. 32: 1153-1160. PMID: 36809342
- NF1-Driven Rhabdomyosarcoma Phenotypes: A Comparative Clinical and Molecular Study of NF1-Mutant Rhabdomyosarcoma and NF1-Associated Malignant Triton Tumor. | de Traux de Wardin, H., et al. 2024. JCO Precis Oncol. 8: e2300597. PMID: 38603649
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
NF-1 Antibody (F-2) | sc-398751 | 200 µg/ml | $316.00 | |||
NF-1 (F-2) Neutralizing Peptide | sc-398751 P | 100 µg/0.5 ml | $68.00 | |||
NF-1 Antibody (F-2) X | sc-398751 X | 200 µg/0.1 ml | $316.00 |