Neutrophil Marker Antibody (NIMP-R14): sc-59338

Neutrophil Marker Antibody (NIMP-R14) is a rat monoclonal IgG2b antibody that detects the Neutrophil Marker protein of mouse origin by immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and flow cytometry (FCM). Anti-Neutrophil Marker antibody (NIMP-R14) is available as the non-conjugated format. Neutrophils, also known as neutrophil granulocytes, are the most abundant type of white blood cell and play a crucial role in the mammalian immune system, particularly in the defense against bacterial infections. These cells are strategically located in the bloodstream and can rapidly migrate to sites of infection or inflammation, where they are often the first responders. Upon arrival, neutrophils engage in phagocytosis, a process that allows them to engulf and destroy pathogens. This is vital for controlling infections and preventing the spread of bacteria. Additionally, neutrophils are equipped with various granules that contain antimicrobial proteins, which are released to combat invading microorganisms. The ability of neutrophils to perform these functions effectively is essential for maintaining immune homeostasis and responding to acute inflammatory challenges.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

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Neutrophil Marker Antibody (NIMP-R14) References:

1. Cohabitation with a sick cage mate: Effects on noradrenaline turnover and neutrophil activity.  |  Alves, GJ., et al. 2006. Neurosci Res. 56: 172-9. PMID: 16971013
2. Sustained G-CSF plasma levels following administration of pegfilgrastim fasten neutrophil reconstitution after high-dose chemotherapy and autologous blood stem cell transplantation in patients with multiple myeloma.  |  Fenk, R., et al. 2006. Exp Hematol. 34: 1296-302. PMID: 16982322
3. Both influenza-induced neutrophil dysfunction and neutrophil-independent mechanisms contribute to increased susceptibility to a secondary Streptococcus pneumoniae infection.  |  McNamee, LA. and Harmsen, AG. 2006. Infect Immun. 74: 6707-21. PMID: 16982840
4. The role of CD69 in acute neutrophil-mediated inflammation.  |  Lamana, A., et al. 2006. Eur J Immunol. 36: 2632-8. PMID: 16983725
5. Rho GTPase Rac1 is critical for neutrophil migration into the lung.  |  Filippi, MD., et al. 2007. Blood. 109: 1257-64. PMID: 16990606
6. Priming by tumor necrosis factor-alpha of human neutrophil NADPH-oxidase activity induced by anti-proteinase-3 or anti-myeloperoxidase antibodies.  |  Reumaux, D., et al. 2006. J Leukoc Biol. 80: 1424-33. PMID: 16997860
7. In vivo regulation of neutrophil apoptosis by C5a during sepsis.  |  Guo, RF., et al. 2006. J Leukoc Biol. 80: 1575-83. PMID: 16997861

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Neutrophil Marker Antibody (NIMP-R14) has 98 citations in a variety of scientific publications.

Primary antibodies like Anti-Neutrophil Marker Antibody (NIMP-R14) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Neutrophil Marker Antibody (NIMP-R14) Specifications

Alternate Product Name: Neutrophil Marker

Product Clone Name: NIMP-R14

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b

Amino Acids:

Epitope Target: Neutrophil Marker

Epitope Species: mouse

Product Reactivity/Detection: neutrophils

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: IF, IHC(P), FCM

Vialing Information: Each vial contains 100 µg IgG_2b in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 98 citations in various scientific publications

Available Conjugates/Forms for Neutrophil Marker Antibody (NIMP-R14): N/A