Neurophysin I Antibody (D-11): sc-393907

Neurophysin I Antibody (D-11) is a mouse monoclonal IgM antibody that detects Neurophysin I of mouse and rat origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Neurophysin I antibody (D-11) is available as a non-conjugated format, providing researchers with a reliable tool for studying this important protein. Neurophysin I plays a crucial role as a carrier protein for oxytocin, a hormone essential for various physiological processes, including inducing uterine contractions during childbirth and facilitating milk ejection during nursing. Neurophysin I synthesis occurs in the supraoptic and paraventricular nuclei of the hypothalamus, where production takes place alongside respective hormones, arginine vasopressin and oxytocin. Neurophysin I interaction with oxytocin is vital for proper transport and release of this hormone, highlighting Neurophysin I significance in reproductive and lactation-related functions. Additionally, Neurophysin I and Neurophysin II are encoded by genes that map to human chromosome 20p13, and both genes consist of three exons, with the middle region being critical for homodimer formation. Conservation of this region underscores significance in functionality, as mutations in this area can lead to disorders such as familial diabetes insipidus. With detection capabilities across multiple applications, Neurophysin I monoclonal antibody (D-11) serves as an invaluable resource for researchers investigating neurophysin roles in endocrine regulation and related pathologies.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Neurophysin I Antibody (D-11) References:

1. The human gene for oxytocin-neurophysin I (OXT) is physically mapped to chromosome 20p13 by in situ hybridization.  |  Rao, VV., et al. 1992. Cytogenet Cell Genet. 61: 271-3. PMID: 1486803
2. Synthesis, transport, and release of posterior pituitary hormones.  |  Brownstein, MJ., et al. 1980. Science. 207: 373-8. PMID: 6153132
3. Vasopressin and central integrative processes.  |  Doris, PA. 1984. Neuroendocrinology. 38: 75-85. PMID: 6320032
4. Cooperative interactions in neurophysin-neuropeptide hormone complexes. Analytical affinity chromatography of native and covalently-modified neurophysins.  |  Abercrombie, DM., et al. 1984. Int J Pept Protein Res. 24: 218-32. PMID: 6500806
5. Recent gene conversion involving bovine vasopressin and oxytocin precursor genes suggested by nucleotide sequence.  |  Ruppert, S., et al. Nature. 308: 554-7. PMID: 6709064
6. Isolation and partial characterization of two human neurophysins: their use in the development of specific radioimmunoassays.  |  North, WG., et al. 1980. J Clin Endocrinol Metab. 51: 884-91. PMID: 7419670
7. Heterologous expression of human vasopressin-neurophysin precursors in a pituitary cell line: defective transport of a mutant protein from patients with familial diabetes insipidus.  |  Olias, G., et al. 1996. DNA Cell Biol. 15: 929-35. PMID: 8945633
8. Central oxytocin and reproductive behaviours.  |  Insel, TR., et al. 1997. Rev Reprod. 2: 28-37. PMID: 9414463

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Neurophysin I Antibody (D-11) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-Neurophysin I Antibody (D-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Neurophysin I Antibody (D-11) Specifications

Alternate Product Name: Neurophysin I

Product Clone Name: D-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 101-127

Epitope Target: Neurophysin I

Epitope Species: mouse

Product Reactivity/Detection: precursor and mature Neurophysin I

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for Neurophysin I Antibody (D-11): P: Blocking Peptide