Date published: 2026-2-15

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Neuropeptide Y (3-36), human (CAS 150138-78-6)

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Application:
Neuropeptide Y (3-36), human is a neuropeptide thought to be associated with food intake
CAS Number:
150138-78-6
Molecular Weight:
4011.48
Molecular Formula:
C175H269N53O54S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Neuropeptide Y (3-36), human, is a truncated form of the neuropeptide Y (NPY) molecule, a neurotransmitter widely distributed in the central and peripheral nervous systems. Research on Neuropeptide Y (3-36), human, has primarily focused on its physiological functions and its role in modulating various biological processes. Mechanistically, Neuropeptide Y (3-36), human, acts as an agonist at specific NPY receptors, including Y2 and Y5 receptor subtypes, which are abundantly expressed in the brain, as well as in peripheral tissues such as adipose tissue and the cardiovascular system. Upon binding to these receptors, Neuropeptide Y (3-36), human, initiates intracellular signaling cascades that regulate neuronal excitability, synaptic transmission, and neuroendocrine secretion. Studies have also implicated Neuropeptide Y (3-36), human, in the regulation of appetite, energy balance, and stress responses, suggesting its involvement in the neuroendocrine control of metabolism and behavior. In research settings, Neuropeptide Y (3-36), human, has been utilized as a tool to investigate the neural circuits and molecular mechanisms underlying these physiological functions, offering insights into the complex interplay between neuropeptides, neurotransmitters, and hormonal signaling pathways. Furthermore, studies have explored the potential implications of Neuropeptide Y (3-36), human, signaling in conditions such as obesity, diabetes, and anxiety disorders, highlighting its relevance as a target for pharmacological interventions. Overall, Neuropeptide Y (3-36), human, serves as a valuable research tool in neurobiology and endocrinology, contributing to our understanding of brain function and its role in regulating systemic physiology and behavior.


Neuropeptide Y (3-36), human (CAS 150138-78-6) References

  1. Neuropeptide Y Y(1) receptor regulates protein turnover and constitutive gene expression in hypertrophying cardiomyocytes.  |  Nicholl, SM., et al. 2002. Eur J Pharmacol. 441: 23-34. PMID: 12007917
  2. Intracerebroventricular injection of a neuropeptide Y-Y1 receptor agonist increases while BIBP3226, a Y1 antagonist, reduces the infarct volume following transient middle cerebral artery occlusion in rats.  |  Chen, SH. and Cheung, RT. 2003. Neuroscience. 116: 119-26. PMID: 12535945
  3. Sitagliptin augments sympathetic enhancement of the renovascular effects of angiotensin II in genetic hypertension.  |  Jackson, EK. and Mi, Z. 2008. Hypertension. 51: 1637-42. PMID: 18443229
  4. Suppression of third ventricular NPY-elicited feeding following medullary reticular formation infusions of muscimol.  |  Travers, JB., et al. 2010. Behav Neurosci. 124: 225-33. PMID: 20364882
  5. Neuropeptide Y3-36 incorporated into PVAX nanoparticle improves functional blood flow in a murine model of hind limb ischemia.  |  Eshun, D., et al. 2017. J Appl Physiol (1985). 122: 1388-1397. PMID: 28302707
  6. Neuropeptide Y3-36 incorporated into PVAX nanoparticle improves angiogenesis in a murine model of myocardial ischemia.  |  Mahmood, E., et al. 2020. Eur J Pharmacol. 882: 173261. PMID: 32534073
  7. Proteolytic processing of neuropeptide Y and peptide YY by dipeptidyl peptidase IV.  |  Mentlein, R., et al. 1993. Regul Pept. 49: 133-44. PMID: 7907802
  8. Neuropeptide Y and neuropeptide Y 3-36: isolation from human pancreatic endocrine tumours.  |  Shaw, C., et al. 1993. Regul Pept. 45: 387-94. PMID: 8351404
  9. Neuropeptide Y phase shifts the circadian clock in vitro via a Y2 receptor.  |  Golombek, DA., et al. 1996. Neuroreport. 7: 1315-9. PMID: 8817557
  10. Neuropeptide Y 3-36 is an endogenous ligand selective for Y2 receptors.  |  Grandt, D., et al. 1996. Regul Pept. 67: 33-7. PMID: 8952003

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Neuropeptide Y (3-36), human, 0.5 mg

sc-396087
0.5 mg
$337.00