neuroligin 1 Antibody (F-5): sc-365111

Neuroligin 1 Antibody (F-5) is a mouse monoclonal IgG1 antibody that detects neuroligin 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Neuroligin 1 is a crucial component of the synaptic architecture, primarily located in the excitatory neuronal synaptic clefts, where neuroligin 1 plays a vital role in synapse formation and remodeling. Neuroligin 1 interacts with β-neurexins, a family of neuronal cell surface proteins, to facilitate the clustering of neurotransmitter receptors and ion channels at synapses, thereby influencing synaptic transmission and plasticity. The binding of neurexin 1β to the EF-hand domain of neuroligin 1 is calcium-dependent, highlighting the importance of calcium ions in synaptic signaling and function. Additionally, neuroligin 1′s interaction with postsynaptic density protein 95 (PSD-95) is essential for the recruitment of signaling molecules and receptors, which are critical for effective synaptic communication. Anti-neuroligin 1 antibody (F-5) is an invaluable tool for researchers studying synaptic dynamics and neurodevelopmental disorders, providing insights into the molecular mechanisms underlying synaptic connectivity and function.

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neuroligin 1 Antibody (F-5) References:

1. CaMKII phosphorylation of neuroligin-1 regulates excitatory synapses.  |  Bemben, MA., et al. 2014. Nat Neurosci. 17: 56-64. PMID: 24336150
2. Abundance and significance of neuroligin-1 and glutamate in Hirschsprung's disease.  |  Wang, J., et al. 2015. World J Gastroenterol. 21: 7172-80. PMID: 26109803
3. Neuroligin-1 Signaling Controls LTP and NMDA Receptors by Distinct Molecular Pathways.  |  Wu, X., et al. 2019. Neuron. 102: 621-635.e3. PMID: 30871858
4. Neuroligin-1 in brain and CSF of neurodegenerative disorders: investigation for synaptic biomarkers.  |  Camporesi, E., et al. 2021. Acta Neuropathol Commun. 9: 19. PMID: 33522967
5. Neuroligin-1-Modified Electrodes for Specific Coupling with a Presynaptic Neuronal Membrane.  |  Jeon, J., et al. 2021. ACS Appl Mater Interfaces. 13: 21944-21953. PMID: 33909393
6. Neuroligin-1 mediates presynaptic maturation through brain-derived neurotrophic factor signaling.  |  Petkova-Tuffy, A., et al. 2021. BMC Biol. 19: 215. PMID: 34579720
7. Postsynaptic Neuroligin-1 Mediates Presynaptic Endocytosis During Neuronal Activity.  |  Luo, JK., et al. 2021. Front Mol Neurosci. 14: 744845. PMID: 34690694
8. Preoperative environment enrichment preserved neuroligin 1 expression possibly via epigenetic regulation to reduce postoperative cognitive dysfunction in mice.  |  Min, J., et al. 2022. CNS Neurosci Ther. 28: 619-629. PMID: 34882968
9. Prenatal glucocorticoid exposure selectively impairs neuroligin 1-dependent neurogenesis by suppressing astrocytic FGF2-neuronal FGFR1 axis.  |  Choi, GE., et al. 2022. Cell Mol Life Sci. 79: 294. PMID: 35562616
10. Neuroligin-1 dependent phosphotyrosine signaling in excitatory synapse differentiation.  |  Szíber, Z., et al. 2024. Front Mol Neurosci. 17: 1359067. PMID: 38813439

The preferred neuroligin 1 antibody is neuroligin 1 Antibody (A-4): sc-365110.