Neurokinin B Antibody (1B2): sc-517127

Neurokinin B Antibody (1B2) is a mouse monoclonal IgG1 kappa light chain antibody that detects Neurokinin B protein of human origin by western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Neurokinin B antibody (1B2) is available as a non-conjugated format. Neurokinin B (NKB), also known as TAC3, NKNB, or ZNEUROK1, is a 121 amino acid secreted protein that plays a crucial role in various physiological processes, including neurotransmission and reproductive functions. NKB protein is primarily expressed in the central and peripheral nervous systems, as well as in the placental outer syncytiotrophoblast, where NKB protein is believed to contribute to pregnancy-related conditions such as pre-eclampsia and hypertension. The significance of NKB extends to involvement in the tachykinin family, which consists of neuropeptides that share a common carboxy-terminal sequence and are known for their diverse biological activities, including modulation of immune responses and angiogenesis. The gene encoding NKB is located on human chromosome 12, a region associated with various genetic disorders, highlighting the importance of NKB in both health and disease. Neurokinin B monoclonal antibody (1B2) is an essential tool for researchers investigating the multifaceted roles of this neuropeptide in human biology.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Neurokinin B Antibody (1B2) References:

1. Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow metastasis.  |  Singh, D., et al. 2000. Proc Natl Acad Sci U S A. 97: 388-93. PMID: 10618428
2. Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia.  |  Page, NM., et al. 2000. Nature. 405: 797-800. PMID: 10866201
3. [Achondrogenesis type II-hypochondrogenesis: radiological features.Case report].  |  Delgado Carrasco, J., et al. 2001. An Esp Pediatr. 55: 553-7. PMID: 11730591
4. A case of Kniest dysplasia with retinal detachment and the mutation analysis.  |  Yokoyama, T., et al. 2003. Am J Ophthalmol. 136: 1186-8. PMID: 14644246
5. A familial case of achondrogenesis type II caused by a dominant COL2A1 mutation and 'patchy' expression in the mosaic father.  |  Forzano, F., et al. 2007. Am J Med Genet A. 143A: 2815-20. PMID: 17994563
6. TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction.  |  Topaloglu, AK., et al. 2009. Nat Genet. 41: 354-358. PMID: 19079066
7. Trisomy 12p and monosomy 4p: phenotype-genotype correlation.  |  Benussi, DG., et al. 2009. Genet Test Mol Biomarkers. 13: 199-204. PMID: 19378504
8. High resolution melting analysis for mutation detection for PTPN11 gene: applications of this method for diagnosis of Noonan syndrome.  |  Lo, FS., et al. 2009. Clin Chim Acta. 409: 75-7. PMID: 19737548
9. Neurokinin B and Neurokinin-3 Receptor Signaling: Promising Developments in the Management of Menopausal Hot Flushes.  |  Modi, M. and Dhillo, WS. 2019. Semin Reprod Med. 37: 125-130. PMID: 31869840
10. Kisspeptin, Neurokinin B and New Players in Reproduction.  |  Dhillo, WS. 2019. Semin Reprod Med. 37: 153-154. PMID: 31972859
11. The Emerging Therapeutic Potential of Kisspeptin and Neurokinin B.  |  Patel, B., et al. 2024. Endocr Rev. 45: 30-68. PMID: 37467734
12. Identification of a delta isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes.  |  Lai, JP., et al. 1998. J Neuroimmunol. 91: 121-8. PMID: 9846828